Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity.

Wu, Lin; Zhang, Yingmei; Wang, Guizhen; Ren, Jun

Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity.

Wu, Lin; Zhang, Yingmei; Wang, Guizhen; Ren, Jun.

Afiliación

Wu L; Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, Shanghai, China.
Zhang Y; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Wang G; Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, Shanghai, China.
Ren J; National Clinical Research Center for Interventional Medicine, Shanghai, China.

JACC Basic Transl Sci ; 9(6): 811-826, 2024 Jun.

Article en En | MEDLINE | ID: mdl-39070280

ABSTRACT

ABSTRACT

Ferroptosis, an iron-dependent form of regulated cell death, has received increasing attention for its pathophysiologic contribution to the onset and development of doxorubicin-induced cardiotoxicity. Moreover, modulation of ferroptosis with specific inhibitors may provide new therapeutic opportunities for doxorubicin-induced cardiotoxicity. Here, we will review the molecular mechanisms and therapeutic promise of targeting ferroptosis in doxorubicin-induced cardiotoxicity.

Palabras clave

cardiotoxicity; doxorubicin; ferroptosis; glutathione metabolism; iron

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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