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Clinically significant prostate cancer detection rate in biopsy-naïve patients with mpMRI and microultrasound topographically discordant lesions: A single-center retrospective analysis.
Dagnino, Filippo; Avolio, Pier Paolo; Fasulo, Vittorio; Piccolini, Andrea; Aljoulani, Muhannad; Moretto, Stefano; Maffei, Davide; Finocchiaro, Alessio; Beatrici, Edoardo; Paciotti, Marco; Saita, Alberto; Lazzeri, Massimo; Hurle, Rodolfo; Buffi, Nicolò M; Casale, Paolo; Lughezzani, Giovanni.
Afiliación
  • Dagnino F; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Avolio PP; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Fasulo V; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Piccolini A; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Aljoulani M; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Moretto S; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Maffei D; Department of Urology, University College London Hospital NHS Foundation Trust, London, UK.
  • Finocchiaro A; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Beatrici E; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Paciotti M; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy.
  • Saita A; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy.
  • Lazzeri M; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy.
  • Hurle R; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy.
  • Buffi NM; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
  • Casale P; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy. Electronic address: paolo.casale@humanitas.it.
  • Lughezzani G; Department of Urology, Humanitas Research Hospital - IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University -Pieve Emanuele, Italy.
Urol Oncol ; 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-39068037
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

Multiparametric magnetic resonance imaging (mpMRI) has improved the detection of clinically significant prostate cancer (csPCa), and microultrasound (micro-US) shows promise in enhancing detection rates. We compared mpMRI-guided targeted biopsy (MTBx) and micro-US-guided targeted biopsy (micro-US-TBx) in biopsy-naïve patients with discordant lesions at micro-US and mpMRI to detect csPCa (grade group ≥2) and clinically insignificant PCa (ciPCa; grade group 1) and assessed the role of nontargeted systematic biopsy (SBx). MATERIAL AND

METHODS:

We analyzed 178 biopsy-naive men with suspected PCa and discordant lesions at mpMRI and micro-US. All patients underwent mpMRI followed by micro-US, the latter being performed immediately before the biopsy. Imaging findings were interpreted blindly, followed by targeted and SBx. Median age was 63 years (IQR, 57-70), median prostate-specific antigen level was 7 ng/mL (IQR, 5-9 ng/mL), and median prostate volume was 49 cm^3 (IQR, 35-64 cm^3). Overall, 86/178 (48%) patients were diagnosed with PCa, 51/178 (29%) with csPCa.

RESULTS:

Micro-USTBx detected csPCa in 36/178 men (20%; 95% CI 26-46), and MTBx detected csPCa in 28/178 men (16%; 95% CI 36-50), resulting in a -8% difference (95% CI -10, 4; P = 0.022) and a relative detection rate of 0.043. Micro-USTBx detected ciPCa in 9/178 men (5%; 95% CI 3, 15), while MTBx detected ciPCa in 12/178 men (7%; 95% CI 5, 20), resulting in a -3% difference (95% CI -2 to 4; P = 0.2) and a relative detection rate of 0.1. SBx detected ciPCa in 29 (16%) men. mpMRI plus micro-US detected csPCa in 51/178 men, with no additional cases with the addition of SBx. Similarly, MTBx plus micro-USTBx plus SBx detected ciPCa in 35/178 men (20%; 95% CI 18, 37) compared to 9 (5%) in the micro-US pathway (P = 0.002) and 14/178 (8%; 95% CI 6, 26) in the mpMRI plus micro-US pathway (P = 0.004).

CONCLUSIONS:

In conclusion, a combined micro-US/mpMRI approach could characterize primary disease in biopsy-naïve patients with discordant lesions, potentially avoiding SBx. Further studies are needed to validate our findings and assess micro-US's role in reducing unnecessary biopsies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Urol Oncol Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Urol Oncol Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos