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Enzymatic cascade reactors on carbon nanotube transistor detecting trace prostate cancer biomarker.
Liu, Wentao; Wang, Xuejun; Dong, Baijun; Liu, Yunqi; Wei, Dacheng.
Afiliación
  • Liu W; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China; Laboratory of Molecular Materials and Devices, Fudan University, Shanghai, 200433, PR China.
  • Wang X; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China; Laboratory of Molecular Materials and Devices, Fudan University, Shanghai, 200433, PR China.
  • Dong B; Institute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China.
  • Liu Y; Laboratory of Molecular Materials and Devices, Fudan University, Shanghai, 200433, PR China.
  • Wei D; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China; Laboratory of Molecular Materials and Devices, Fudan University, Shanghai, 200433, PR China. Electronic address: weidc@fudan.edu.cn.
Biosens Bioelectron ; 263: 116603, 2024 Nov 01.
Article en En | MEDLINE | ID: mdl-39067414
ABSTRACT
Biosensors based on carbon nanotube field-effect transistors (CNT-FETs) have shown great potential in biomarker detection due to their high sensitivity because of appreciable semiconducting electrical properties. However, background signal interferences in complex mediums may results in low signal-to-noise ratio, which may impose challenges for precise biomarker detection in physiological fluids. In this work, we develop an enzymatic CNT-FET, with scalable production at wafer scale, for detection of trace sarcosine that is a biopsy-correlated biomarker of prostate cancer. Enzymatic cascade rectors are constructed on the CNT to improve the reaction efficiency, thereby, enhancing the signal transduction. As such, a limit of detection as low as 105 zM is achieved in buffer solution. Owing to the enhanced reaction efficiency, the testing of clinical serum samples yields significant signal difference to discriminate the prostate cancer (PCa) samples from the benign prostatic hyperplasia (BPH) samples (P = 1.07 × 10-5), demonstrating immense potential in practical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Transistores Electrónicos / Técnicas Biosensibles / Biomarcadores de Tumor / Nanotubos de Carbono Límite: Humans / Male Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Transistores Electrónicos / Técnicas Biosensibles / Biomarcadores de Tumor / Nanotubos de Carbono Límite: Humans / Male Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido