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Preliminary investigation of endoscopic surgery for tympanic membrane perforation: Regenerative treatment compared with conventional surgery.
Asako, Airi; Hidaka, Hiroshi; Kouda, Katsuyasu; Kanemaru, Shin-Ichi; Shimamura, Akira; Iwai, Hiroshi.
Afiliación
  • Asako A; Department of Otolaryngology-Head and Neck Surgery, Kansai Medical University, Hirakata, Japan.
  • Hidaka H; Department of Otolaryngology-Head and Neck Surgery, Kansai Medical University, Hirakata, Japan. Electronic address: ZAY00015@nifty.com.
  • Kouda K; Department of Hygiene and Public Health, Kansai Medical University, Hirakata, Japan.
  • Kanemaru SI; Department of Otolaryngology, Head and Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka, Japan.
  • Shimamura A; Department of Otolaryngology-Head and Neck Surgery, Kansai Medical University, Hirakata, Japan.
  • Iwai H; Department of Otolaryngology-Head and Neck Surgery, Kansai Medical University, Hirakata, Japan.
Am J Otolaryngol ; 45(5): 104408, 2024.
Article en En | MEDLINE | ID: mdl-39067094
ABSTRACT

PURPOSE:

To compare surgical outcomes of regenerative treatment (RT) including basic fibroblast growth factor (bFGF) (Group-R) with the conventional method (Group-C) for patients with tympanic membrane perforation (TMP), both of whom underwent transcanal endoscopic ear surgery.

METHODS:

The study population of Group-R included 61 ears of 59 patients treated with RT-TMP in which TMP edges were disrupted mechanically and a gelatin sponge immersed in bFGF was inserted into the TMP. Fibrin glue was then dripped over the sponge. Group-C consisted of 13 patients who underwent conventional surgery before adopting the RT-TMP. Patients' characteristics and outcomes including TMP closure rates, and change in hearing level were evaluated three or more weeks after the surgery.

RESULTS:

The baseline characteristics including size of TMP were not significantly different between the two groups. Although Group-R had significantly shorter operating time than Group-C, the complete TMP closure rates were 69 % (9/13) and 85 % (52/61), respectively. Air-conduction hearing thresholds showed significant improvements, and analysis of variance showed that Group-R achieved significant interactions other than at 8 kHz, implying better improvement in cases with TMP closure. The air-bone gaps also improved at all frequencies in both groups. Specifically, at 4 kHz, there was a trend showing better improvement in Group-R.

CONCLUSION:

RT-TMP had a high TMP closure rate and good hearing improvement, with no significant differences compared with those of conventional surgery. This new therapy is simple and safe, and requires less operating time, and it could help improve the quality of life of patients with TMP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perforación de la Membrana Timpánica / Endoscopía Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Otolaryngol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perforación de la Membrana Timpánica / Endoscopía Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Otolaryngol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos