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Differences in gray matter atrophy and functional connectivity between motor subtypes of Parkinson's disease.
Yin, Lei; Zhu, Zhigang; Fu, Jialong; Zhou, Chuanbin; Liu, Zhaochao; Li, Yuxia; Luo, Zhenglong; Zhu, Yongyun; Xu, Zhong; Yang, Xinglong.
Afiliación
  • Yin L; The First People's Hospital of Honghe Prefecture, Honghe, 661100, China.
  • Zhu Z; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Fu J; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Zhou C; The First People's Hospital of Honghe Prefecture, Honghe, 661100, China.
  • Liu Z; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
  • Li Y; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Luo Z; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Zhu Y; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Xu Z; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Yang X; The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. xz0702@126.com.
Acta Neurol Belg ; 2024 Jul 27.
Article en En | MEDLINE | ID: mdl-39066885
ABSTRACT
Parkinson's disease (PD) patients with postural gait abnormalities exhibit poorer motor function scores, more severe non-motor symptoms, faster cognitive function deterioration, and a less favorable response to drugs and surgery compared to PD patients with tremor. This discrepancy is believed to be associated with more pronounced gray matter atrophy and abnormal functional connectivity. To investigate the distinctive pathological mechanisms between PD subtypes, we examined gray matter volume (GMV) and functional connectivity in patients with Parkinson's disease presenting with postural instability/gait difficulty (PD-PIGD), patients with tremor-dominant Parkinson's disease (PD-TD), and healthy controls. Voxel-based morphometry (VBM) of T1-weighted images was conducted to compare GMV among 64 PD-PIGD patients, 44 PD-TD patients, and 32 controls. Subsequently, functional connectivity within regions showing reduced GMV was compared across the groups. We analyzed whether differences among the groups were associated with clinical characteristics and neuroimaging biomarkers using partial correlation and binary logistic regression. Our comparison between PD-PIGD and PD-TD patients revealed a link between PD-PIGD and more extensive frontotemporal atrophy, potentially indicating increased basal ganglia activity accompanied by decreased cerebellum activity. Furthermore, in addition to the smaller GMV in the left middle temporal gyrus, the increased functional connectivity between this brain region and the right caudate was also the independent risk factor for PD-PIGD. In addition, we compared brain network connectivity between the PIGD and TD subtypes, using an independent component analysis (ICA). We found that Compared to PD-TD, PD-PIGD patients showed an enhanced sensorimotor network (SMN) around the left supplementary motor area. These findings suggest that severe gray matter atrophy and abnormal functional connectivity and brain networks may serve as pathophysiological mechanisms distinguishing PD-PIGD patients from other subtypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Neurol Belg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Neurol Belg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia