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PROX1 is a regulator of neuroendocrine-related gene expression in lung carcinoid.
Sakurai, Kouhei; Ando, Tatsuya; Sakai, Yasuhiro; Mori, Yuichiro; Nakamura, Satoru; Kato, Taku; Ito, Hiroyasu.
Afiliación
  • Sakurai K; Department of Joint Research Laboratory of Clinical Medicine, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan. kouhei.sakurai@fujita-hu.ac.jp.
  • Ando T; Department of Joint Research Laboratory of Clinical Medicine, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
  • Sakai Y; Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, 431-3192, Japan.
  • Mori Y; School of Medicine, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.
  • Nakamura S; Department of Joint Research Laboratory of Clinical Medicine, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
  • Kato T; Central Research Laboratory, Nitto Fuji Flour Milling Co., Ltd., Tokyo, 143-0001, Japan.
  • Ito H; Department of Joint Research Laboratory of Clinical Medicine, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Hum Cell ; 37(5): 1559-1566, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39066858
ABSTRACT
Lung neuroendocrine neoplasms (NENs) are a diverse group of tumors characterized by neuroendocrine (NE) differentiation. Among lung NENs, lung carcinoid (LC) is a rare tumor with unique characteristics. Recent research has highlighted the importance of transcription factors (TFs) in establishing gene expression programs in lung NENs such as small cell lung carcinoma. However, the TFs that control the gene expression of LC are largely unknown. In this study, we report the expression and potential function of a TF called Prospero homeobox protein1 (PROX1) in LC. Publicly available transcriptome data suggested that PROX1 was highly expressed in LC tissues, which was confirmed by immunohistochemical analysis on a tissue microarray. Knockdown of PROX1 did not impact the cellular viability of an LC-derived cell line, NCI-H727. Meanwhile, transcriptome analysis revealed that PROX1 knockdown altered the expression of genes involved in NE differentiation. ASCL1, CHGA, CALCA, and LINC00261 were suggested as downstream genes of PROX1. These findings indicate that PROX1 may play an important role in the NE identity of LC by regulating the expression of key target genes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tumor Carcinoide / Regulación Neoplásica de la Expresión Génica / Diferenciación Celular / Proteínas de Homeodominio / Proteínas Supresoras de Tumor / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Hum Cell Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tumor Carcinoide / Regulación Neoplásica de la Expresión Génica / Diferenciación Celular / Proteínas de Homeodominio / Proteínas Supresoras de Tumor / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Hum Cell Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón