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Demonstration of Tunable Control over a Delayed-Release Vaccine Using Atomic Layer Deposition.
Brubaker, Sky W; Walters, Isabella R; Hite, Emily M; Antunez, Lorena R; Palm, Emma L; Funke, Hans H; Steadman, Bryan L.
Afiliación
  • Brubaker SW; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
  • Walters IR; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
  • Hite EM; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
  • Antunez LR; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
  • Palm EL; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
  • Funke HH; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
  • Steadman BL; VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
Vaccines (Basel) ; 12(7)2024 Jul 11.
Article en En | MEDLINE | ID: mdl-39066399
ABSTRACT
Many vaccines require multiple doses for full efficacy, posing a barrier for patient adherence and protection. One solution to achieve full vaccination may be attained with single-administration vaccines containing multiple controlled release doses. In this study, delayed-release vaccines were generated using atomic layer deposition (ALD) to coat antigen-containing powders with alumina. Using in vitro and in vivo methods, we show that increasing the coat thickness controls the kinetics of antigen release and antibody response, ranging from weeks to months. Our results establish an in vitro-in vivo correlation with a level of tunable control over the antigen release and antibody response times with the potential to impact future vaccine design.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza