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Anti-Human Immunodeficiency Virus-1 Property of Thai Herbal Extract Kerra™.
Saehlee, Siriwan; Seetaha, Supaphorn; Klankaew, Wiwat; Srathong, Pussadee; Choowongkomon, Kiattawee; Choengpanya, Khuanjarat.
Afiliación
  • Saehlee S; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Seetaha S; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Klankaew W; Interdisciplinary of Genetic Engineering and Bioinformatics, Graduate School, Kasetsart University, Bangkok 10900, Thailand.
  • Srathong P; Faculty of Nursing, Praboromarajchanok Institute, Nonthaburi 11000, Thailand.
  • Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Choengpanya K; Interdisciplinary of Genetic Engineering and Bioinformatics, Graduate School, Kasetsart University, Bangkok 10900, Thailand.
Pharmaceuticals (Basel) ; 17(7)2024 Jul 09.
Article en En | MEDLINE | ID: mdl-39065767
ABSTRACT
Kerra™, a Thai traditional herbal medicine derived from the "Tak-Ka-Si-La Scripture" and composed of nine medicinal plants, has demonstrated potential antiviral properties against HIV. This study investigated the inhibitory effects of Kerra™ on HIV-1 reverse transcriptase (RT) and its ability to prevent pseudo-HIV viral infection in HEK293 cells. The results showed that Kerra™ extract achieved a 95.73 ± 4.24% relative inhibition of HIV-1 RT, with an IC50 value of 42.66 ± 8.74 µg/mL. Docking studies revealed that key phytochemicals in Kerra™, such as oleamide, formononetin, and biochanin A, interact with several residues in the RT non-nucleoside binding pocket, contributing to their inhibitory effects. Furthermore, Kerra™ was able to reduce pseudo-HIV infection in HEK293 cells at a concentration of 10 µg/mL, suggesting its potential as a supplementary treatment for HIV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza