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Brown Algae as a Valuable Substrate for the Cost-Effective Production of Poly-γ-Glutamic Acid for Applications in Cream Formulations.
Parati, Mattia; Philip, Catherine; Allinson, Sarah L; Mendrek, Barbara; Khalil, Ibrahim; Tchuenbou-Magaia, Fideline; Kowalczuk, Marek; Adamus, Grazyna; Radecka, Iza.
Afiliación
  • Parati M; Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1 LY, UK.
  • Philip C; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UK.
  • Allinson SL; Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1 LY, UK.
  • Mendrek B; Biomedical and Life Sciences, Lancaster University, Furness Building, Lancaster LA1 4YG, UK.
  • Khalil I; Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland.
  • Tchuenbou-Magaia F; Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1 LY, UK.
  • Kowalczuk M; Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1 LY, UK.
  • Adamus G; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UK.
  • Radecka I; Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland.
Polymers (Basel) ; 16(14)2024 Jul 22.
Article en En | MEDLINE | ID: mdl-39065408
ABSTRACT
Poly-γ-glutamic acid (γ-PGA) is a carboxylic-acid-rich, bio-derived, water-soluble, edible, hydrating, non-immunogenic polymer produced naturally by several microorganisms. Here, we re-emphasise the ability of Bacillus subtilis natto to naturally produce γ-PGA on whole seaweed, as well as for the yields and chemical properties of the material to be affected by the presence of Mn(2+). Hyaluronic acid (HA) is an extracellular glycosaminoglycan which presents a high concentration of carboxylic acid and hydroxyl groups, being key in fulfilling numerous applications. Currently, there are strong environmental (solvent use), social (non-vegan extraction), and economic factors pushing for the biosynthesis of this material through prokaryotic microorganisms, which is not yet scalable or sustainable. Our study aimed to investigate an innovative raw material which can combine both superior hygroscopicity and UV protection to the cosmetic industry. Comparable hydration effect of commercially available γ-PGA to conventional moisturising agents (HA and glycerol) was observed; however, greater hydration capacity was observed from seaweed-derived γ-PGA. Herewith, successful incorporation of seaweed-derived γ-PGA (0.2-2 w/v%) was achieved for several model cream systems with absorbances reported at 300 and 400 nm. All γ-PGA-based creams displayed shear thinning behaviour as the viscosity decreased, following increasing shear rates. Although the use of commercial γ-PGA within creams did not suggest a significant effect in rheological behaviour, this was confirmed to be a result of the similar molecular weight. Seaweed-derived γ-PGA cream systems did not display any negative effect on model HaCaT keratinocytes by means of in vitro MTT analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza