Multiple Functions of Hepatitis E Virus ORF3.

Jiao, Fengyuan; Zhao, Yu; Zhou, Gengxu; Meng, Chi; Wang, Lingjie; Wu, Shengping; Li, Jixiang; Cao, Liting; Zhou, Bo; Luo, Yichen; Jiao, Hanwei

Jiao, Fengyuan; Zhao, Yu; Zhou, Gengxu; Meng, Chi; Wang, Lingjie; Wu, Shengping; Li, Jixiang; Cao, Liting; Zhou, Bo; Luo, Yichen; Jiao, Hanwei.

Afiliación

Jiao F; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Zhao Y; Ministry of Agriculture and Rural Affairs Key Laboratory of Crop Genitic Resources and Germplasm Innovation in Karst Region, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Science, Guiyang 550005, China.
Zhou G; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Meng C; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Wang L; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Wu S; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Li J; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Cao L; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Zhou B; Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yujinxiang Street 573, Changchun 130102, China.
Luo Y; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Jiao H; The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.

Microorganisms ; 12(7)2024 Jul 11.

Article en En | MEDLINE | ID: mdl-39065173

ABSTRACT

ABSTRACT

Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen, HEV, has three Open Reading Frames (ORFs) ORF1, ORF2, and ORF3, each of which has a different function. Most of the current research is focused on ORF1 and ORF2, while the research on ORF3 is still relatively small. To provide more ideas for the study of HEV pathogenesis and the prevention and treatment of HE, this paper reviews the effects of ORF3 on the ERK pathway, growth factors, immune response, and virus release.

Palabras clave

HE; HEV; ORF3

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microorganisms Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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