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Mollaret's Meningitis due to Herpes Simplex Virus 2: A Case Report and Review of the Literature.
Gabrielli, Liliana; Banchini, Isabella; Petrisli, Evangelia; Piccirilli, Giulia; Venturoli, Simona; Pavoni, Matteo; Cantiani, Alessia; Lanna, Federica; Campoli, Caterina; Montironi, Matteo; Giannella, Maddalena; Lazzarotto, Tiziana.
Afiliación
  • Gabrielli L; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Banchini I; Department of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
  • Petrisli E; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Piccirilli G; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Venturoli S; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Pavoni M; Department of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
  • Cantiani A; Department of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
  • Lanna F; Department of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
  • Campoli C; Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Montironi M; Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Giannella M; Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Lazzarotto T; Department of Medical and Surgical Sciences, Infectious Diseases Section, Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Microorganisms ; 12(7)2024 Jul 03.
Article en En | MEDLINE | ID: mdl-39065131
ABSTRACT
Mollaret's meningitis is a rare neurological disorder characterized by recurrent episodes of aseptic lymphocytic meningitis, often associated with herpes simplex virus 2 (HSV-2) infection. We report the case of a 39 y.o. Italian woman who experienced four episodes of aseptic lymphocytic meningitis between 2004 and 2023, diagnosed as Mollaret's meningitis. In each episode, the patient presented with fever, severe headache and photophobia. In two episodes cutaneous vesicles in the left gluteal area preceding meningitis symptoms were also reported. A diagnostic evaluation included a physical-chemical analysis and a real-time PCR of the cerebrospinal fluid (CSF). The CSF presented pleocytosis with lymphocytic predominance and a positive HSV-2 load, with a peak of 1234 copies/mL. The patient was treated successfully with acyclovir, and the symptoms resolved without neurological sequelae. This case highlights the importance of comprehensive diagnostic testing and vigilant monitoring to manage Mollaret's syndrome effectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microorganisms Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microorganisms Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza