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Cellular Senescence in Germ Cell Neoplasia In Situ (GCNIS) and Other Histological Types of Testicular Cancer.
Tatanis, Vasileios; Veroutis, Dimitris; Pantelis, Pavlos; Theocharous, George; Sarlanis, Helen; Georgiou, Alexandros; Mulita, Francesk; Peteinaris, Angelis; Natsos, Anastasios; Moulavasilis, Napoleon; Kavantzas, Nikolaos; Kotsinas, Athanassios; Adamakis, Ioannis.
Afiliación
  • Tatanis V; Department of Urology, University of Patras, 26504 Patras, Greece.
  • Veroutis D; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Pantelis P; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Theocharous G; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Sarlanis H; Department of Pathology, Medical School, National and Kapodistrian University, 10680 Athens, Greece.
  • Georgiou A; Department of Pathology, Medical School, National and Kapodistrian University, 10680 Athens, Greece.
  • Mulita F; Department of Surgery, University Hospital of Patras, 26504 Patras, Greece.
  • Peteinaris A; Department of Urology, University of Patras, 26504 Patras, Greece.
  • Natsos A; Department of Urology, University of Patras, 26504 Patras, Greece.
  • Moulavasilis N; 1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 10680 Athens, Greece.
  • Kavantzas N; Department of Pathology, Medical School, National and Kapodistrian University, 10680 Athens, Greece.
  • Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Adamakis I; 1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 10680 Athens, Greece.
Medicina (Kaunas) ; 60(7)2024 Jul 08.
Article en En | MEDLINE | ID: mdl-39064537
ABSTRACT
Background and

Objectives:

The presence and contribution of senescent cells in premalignant lesions is well documented, but not in germ cell neoplasia in situ. The purpose of this study is to identify the presence of senescent cells in pre-malignant testicular conditions and in different histological types of testicular cancer. Materials and

Methods:

Thirty patients who underwent orchiectomy due to testicular tumors were included. Formalin-fixed paraffin-embedded (FFPE) testicular tissue for each patient was available. Sections from these specimens were examined by immunohistochemical analysis with the following markers GL13 for cellular senescence, p21WAF1/Cip1 for cell cycle arrest, and Ki67 for cell proliferation.

Results:

Thirteen (43.3%) suffered from seminoma with a mean total proportion of GCNIS senescence of 20.81 ± 6.81%. In the group of embryonal testicular tumors, nine (30%) patients were included, with an average rate of 6.64 ± 5.42% of senescent cells in GCNIS. One (3.3%) patient suffered from chondrosarcoma in which 7.9% of GL13+ cells were detected in GCNIS. Four (13.4%) patients suffered from teratoma and three (10%) from yolk sac tumors, while GCNIS senescence was detected in a range of 4.43 ± 1.78% and 3.76 ± 1.37%, respectively.

Conclusions:

Cellular senescence was detected in both germ cell neoplasia in situ and testicular cancer, but was more prevalent within the premalignant lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Senescencia Celular / Neoplasias de Células Germinales y Embrionarias Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Senescencia Celular / Neoplasias de Células Germinales y Embrionarias Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza