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Cardiovascular and All-Cause Mortality Is Affected by Serum Magnesium and Diet Pattern in a Cohort of Dialysis Patients.
Petrakis, Ioannis; Bacharaki, Dimitra; Kyriazis, Periklis; Balafa, Olga; Dounousi, Evangelia; Tsirpanlis, George; Theodoridis, Marios; Tsotsorou, Ourania; Markaki, Anastasia; Georgoulidou, Anastasia; Triantafyllis, George; Giannikouris, Ioannis; Kokkalis, Apostolos; Stavroulopoulos, Aristeides; Stylianou, Kostas.
Afiliación
  • Petrakis I; Nephrology Department, University General Hospital of Heraklion, 71500 Heraklion, Greece.
  • Bacharaki D; Nephrology Department, Attikon University Hospital, 12462 Athens, Greece.
  • Kyriazis P; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Balafa O; Nephrology Department, University Hospital of Ioannina, 45500 Ioannina, Greece.
  • Dounousi E; Nephrology Department, University Hospital of Ioannina, 45500 Ioannina, Greece.
  • Tsirpanlis G; Nephrology Department, General Hospital of Athens "G. Gennimatas", 11527 Athens, Greece.
  • Theodoridis M; Department of Nephrology, Democritus University of Thrace, 68150 Alexandroupolis, Greece.
  • Tsotsorou O; Nephrology Department, Attikon University Hospital, 12462 Athens, Greece.
  • Markaki A; Department of Nutrition and Dietetics, Hellenic Mediterranean University, 71410 Heraklion, Greece.
  • Georgoulidou A; Nephrology Department, General Hospital of Komotini, 69133 Komotini, Greece.
  • Triantafyllis G; Department of Nephrology, Hemodialysis Unit, Mediterraneo Hospital, 16675 Glyfada, Greece.
  • Giannikouris I; Department of Nephrology, Hemodialysis Unit, Mediterraneo Hospital, 16675 Glyfada, Greece.
  • Kokkalis A; Ionio Salaminas Hemodialysis Center, 18900 Salamina, Greece.
  • Stavroulopoulos A; Nephrology Department, General Clinic of Kalithea, IASIO Hospital, 17675 Athens, Greece.
  • Stylianou K; NEPHROEXPERT-Athens Kidney Institute, 17675 Athens, Greece.
J Clin Med ; 13(14)2024 Jul 10.
Article en En | MEDLINE | ID: mdl-39064068
ABSTRACT

Background:

Hypomagnesaemia is associated with an increased overall mortality in patients with chronic kidney disease on dialysis (CKD-5D). Mediterranean-style diet (MD), having a high magnesium content, can serve as a form of dietary magnesium supplementation. We examined whether there is a potential link between increased Mediterranean Diet score (MDS) and elevated serum magnesium (sMg) to assess its impact on reducing mortality risk in CKD-5D patients.

Methods:

In this multi-center prospective observational study, 117 CKD-5D patients (66 on hemodialysis and 51 on peritoneal dialysis) with a mean age of 62 ± 15 years were studied for a median follow-up period of 68 months. After baseline assessment, including measurement of sMg and MDS, all patients were followed up for cardiovascular (CV) and all-cause mortality.

Results:

Forty deaths occurred, 58% of which were cardiovascular. Patients who were above the median value of sMg (2.2 mg/dL) had a 66% reduction in CV (crude HR, 0.34; 95% CI, 0.11-0.70), and 49% reduction in all-cause (crude HR, 0.51; 95% CI, 0.27-0.96) mortality, even after adjustment for age, malnutrition inflammation score, left ventricular mass index, peripheral vascular disease and diabetes. Similar results were obtained when sMg was analyzed as a continuous variable. sMg was associated directly with MDS (r = 0.230; p = 0.012).

Conclusions:

Higher sMg levels are strongly and independently associated with reduced CV and all-cause mortality in CKD-5D patients. A strong correlation exists between MDS and sMg. Elevated sMg levels, achieved through MD adherence, can significantly reduce CV mortality, implicating MD as a mediator of the association between sMg and CV mortality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza