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Sex Differences in Fractional Flow Reserve Utilization.
Bujak, Marta; Malinowski, Krzysztof; Siudak, Zbigniew; Cmiel, Anna; Lesiak, Maciej; Bartus, Stanislaw; Legutko, Jacek; Wanha, Wojciech; Witkowski, Adam; Dudek, Dariusz; Gasior, Mariusz; Gil, Robert; Protasiewicz, Marcin; Kubica, Jacek; Godek, Piotr; Wojakowski, Wojciech; Gasior, Pawel.
Afiliación
  • Bujak M; Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, 40-055 Katowice, Poland.
  • Malinowski K; Department of Bioinformatics and Telemedicine, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland.
  • Siudak Z; Center for Digital Medicine and Robotics, Jagiellonian University Medical College, 31-008 Krakow, Poland.
  • Cmiel A; Faculty of Medicine and Health Sciences, Jan Kochanowski University, 25-369 Kielce, Poland.
  • Lesiak M; Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, 40-055 Katowice, Poland.
  • Bartus S; 1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Legutko J; 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 31-008 Krakow, Poland.
  • Wanha W; Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, 31-202 Krakow, Poland.
  • Witkowski A; Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, 40-055 Katowice, Poland.
  • Dudek D; Department of Interventional Cardiology and Angiology, National Institute of Cardiology, 04-628 Warszawa, Poland.
  • Gasior M; Institute of Cardiology, Jagiellonian University Medical College, 31-008 Krakow, Poland.
  • Gil R; 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
  • Protasiewicz M; Silesian Center for Heart Diseases, 41-800 Zabrze, Poland.
  • Kubica J; Department of Cardiology, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.
  • Godek P; Institute of Heart Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Wojakowski W; Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, 87-100 Torun, Poland.
  • Gasior P; Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, 40-055 Katowice, Poland.
J Clin Med ; 13(14)2024 Jul 10.
Article en En | MEDLINE | ID: mdl-39064067
ABSTRACT

Background:

The literature review shows that female patients are more frequently underdiagnosed or suffer from delayed diagnosis. Recognition of sex-related differences is crucial for implementing strategies to improve cardiovascular outcomes. We aimed to assess sex-related disparities in the frequency of fractional flow reserve (FFR)-guided procedures in patients who underwent angiography and/or percutaneous coronary intervention (PCI).

Methods:

We have derived the data from the national registry of percutaneous coronary interventions and retrospectively analyzed the data of more than 1.4 million angiography and/or PCI procedures [1,454,121 patients (62.54% men and 37.46% women)] between 2014 and 2022. The logistic regression analysis was conducted to explore whether female sex was associated with FFR utilization.

Results:

The FFR was performed in 61,305 (4.22%) patients and more frequently in men than women (4.15% vs. 3.45%, p < 0.001). FFR was more frequently assessed in females with acute coronary syndrome than males (27.75% vs. 26.08%, p < 0.001); however, women with chronic coronary syndrome had FFR performed less often than men (72.25% vs. 73.92%, p < 0.001). Females with FFR-guided procedures were older than men (69.07 (±8.87) vs. 65.45 (±9.38) p < 0.001); however. less often had a history of myocardial infarction (MI) (24.79% vs. 36.73%, p < 0.001), CABG (1.62% vs. 2.55%, p < 0.005) or PCI (36.6% vs. 24.79%, p < 0.001) compared to men. Crude comparison has shown that male sex was associated with a higher frequency of FFR assessment (OR = 1.2152-1.2361, p < 0.005).

Conclusions:

Despite a substantial rise in FFR utilization, adoption in women remains lower than in men. Female sex was found to be an independent negative predictor of FFR use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza