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Systemic Inflammatory Changes in Spinal Cord Injured Patients after Adding Aquatic Therapy to Standard Physiotherapy Treatment.
Agulló-Ortuño, María Teresa; Romay-Barrero, Helena; Lambeck, Johan; Blanco-Calonge, Juan M; Arroyo-Fernández, Rubén; Geigle, Paula Richley; Menchero, Raquel; Corral, Gonzalo Melgar Del; Martínez-Galán, Inés.
Afiliación
  • Agulló-Ortuño MT; Department of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Romay-Barrero H; Research Group on Water and Health (GIAS), University of Castilla-La Mancha. Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Lambeck J; Department of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Blanco-Calonge JM; Research Group on Water and Health (GIAS), University of Castilla-La Mancha. Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Arroyo-Fernández R; Association International Aquatic Therapy Faculty, 7324 Valens, Switzerland.
  • Geigle PR; Department of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Menchero R; Research Group on Water and Health (GIAS), University of Castilla-La Mancha. Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Corral GMD; Department of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.
  • Martínez-Galán I; Research Group on Water and Health (GIAS), University of Castilla-La Mancha. Avda. Carlos III s/n, 45071 Toledo, Spain.
Int J Mol Sci ; 25(14)2024 Jul 21.
Article en En | MEDLINE | ID: mdl-39063208
ABSTRACT
Spinal cord injury (SCI) is a severe medical condition resulting in substantial physiological and functional consequences for the individual. People with SCI are characterised by a chronic, low-grade systemic inflammatory state, which contributes to further undesirable secondary injuries. This study aimed to evaluate the effect of adding aquatic therapy to the standard physiotherapy treatment, implemented in two different schedules, on systemic inflammation in SCI patients. Additionally, the relationship between cytokine blood levels and changes in functionality (measured with the 6MWT, 10MWT, WISCI, BBS, and TUG tests) throughout the study was assessed. A quantitative multiplexed antibody assay was performed to measure the expression level of 20 pro- and anti-inflammatory cytokines in blood samples from SCI patients at three time points baseline, week 6, and immediately post-intervention (week 12). This study identified a complex signature of five cytokines (IL-12p70, IL-8, MCP-1, IL-1α, and IP10) associated with the time course of the two physiotherapy programs. Two other cytokines (IL-4 and TNF-α) were also associated with the functional recovery of patients. These could be important indicators for SCI prognosis and provide a basis for developing novel targeted therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Citocinas / Modalidades de Fisioterapia Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Citocinas / Modalidades de Fisioterapia Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza