Your browser doesn't support javascript.
loading
The Inflammasome Adaptor Protein ASC in Plasma as a Biomarker of Early Cognitive Changes.
Cyr, Brianna; Curiel Cid, Rosie; Loewenstein, David; Vontell, Regina T; Dietrich, W Dalton; Keane, Robert W; de Rivero Vaccari, Juan Pablo.
Afiliación
  • Cyr B; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.
  • Curiel Cid R; Center for Cognitive Neuroscience and Aging, University of Miami, Miami, FL 33136, USA.
  • Loewenstein D; Center for Cognitive Neuroscience and Aging, University of Miami, Miami, FL 33136, USA.
  • Vontell RT; Department of Neurology, University of Miami, Miami, FL 33136, USA.
  • Dietrich WD; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.
  • Keane RW; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.
  • de Rivero Vaccari JP; Department of Physiology and Biophysics, University of Miami, Miami, FL 33136, USA.
Int J Mol Sci ; 25(14)2024 Jul 16.
Article en En | MEDLINE | ID: mdl-39063000
ABSTRACT
Dementia is a group of symptoms including memory loss, language difficulties, and other types of cognitive and functional impairments that affects 57 million people worldwide, with the incidence expected to double by 2040. Therefore, there is an unmet need to develop reliable biomarkers to diagnose early brain impairments so that emerging interventions can be applied before brain degeneration. Here, we performed biomarker analyses for apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid-ß 42/40 (Aß42/40) ratio in the plasma of older adults. Participants had blood drawn at baseline and underwent two annual clinical and cognitive evaluations. The groups tested either cognitively normal on both evaluations (NN), cognitively normal year 1 but cognitively impaired year 2 (NI), or cognitively impaired on both evaluations (II). ASC was elevated in the plasma of the NI group compared to the NN and II groups. Additionally, Aß42 was increased in the plasma in the NI and II groups compared to the NN group. Importantly, the area under the curve (AUC) for ASC in participants older than 70 years old in NN vs. NI groups was 0.81, indicating that ASC is a promising plasma biomarker for early detection of cognitive decline.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Péptidos beta-Amiloides / Proteínas Adaptadoras de Señalización CARD / Disfunción Cognitiva Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Péptidos beta-Amiloides / Proteínas Adaptadoras de Señalización CARD / Disfunción Cognitiva Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza