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Cytomegalovirus in Adenoma and Carcinoma Lesions: Detecting Mono-Infection and Co-Infection in Salivary Glands.
Guimarães, Ana Carolina Silva; Raposo Vedovi, Jéssica Vasques; de Almeida Ribeiro, Camilla Rodrigues; Martinelli, Katrini Guidolini; Pelajo Machado, Marcelo; de Abreu Manso, Pedro Paulo; Euzebio Pereira Dias de Oliveira, Barbara Cristina; Bergamini, Mariana Lobo; de Rosa, Catharina Simioni; Tozetto-Mendoza, Tania Regina; Fernandes de Souza, Ana Carolina Mamana; Martins, Marília Trierveiler; Braz-Silva, Paulo Henrique; de Paula, Vanessa Salete.
Afiliación
  • Guimarães ACS; Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
  • Raposo Vedovi JV; Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
  • de Almeida Ribeiro CR; Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
  • Martinelli KG; Social Medicine Department, Federal University of Espírito Santo, Espirito Santo CEP 2975-910, Brazil.
  • Pelajo Machado M; Pathology Laboratory, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
  • de Abreu Manso PP; Pathology Laboratory, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
  • Euzebio Pereira Dias de Oliveira BC; Pathology Laboratory, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
  • Bergamini ML; Stomatology Department, Dentistry School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
  • de Rosa CS; Stomatology Department, Dentistry School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
  • Tozetto-Mendoza TR; Virology Laboratory, Tropical Medicine Institute of São Paulo, Medical School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
  • Fernandes de Souza ACM; Virology Laboratory, Tropical Medicine Institute of São Paulo, Medical School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
  • Martins MT; Stomatology Department, Dentistry School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
  • Braz-Silva PH; Stomatology Department, Dentistry School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
  • de Paula VS; Virology Laboratory, Tropical Medicine Institute of São Paulo, Medical School, University of São Paulo, São Paulo CEP 05508-000, Brazil.
Int J Mol Sci ; 25(14)2024 Jul 09.
Article en En | MEDLINE | ID: mdl-39062747
ABSTRACT
Salivary glands' neoplasms are hard to diagnose and present a complex etiology. However, several viruses have been detected in these neoplasms, such as HCMV, which can play a role in certain cancers through oncomodulation. The co-infections between HCMV with betaherpesviruses (HHV-6 and HHV-7) and polyomaviruses (JCV and BKV) has been investigated. The aim of the current study is to describe the frequency of HCMV and co-infections in patients presenting neoplastic and non-neoplastic lesions, including in the salivary gland. Multiplex quantitative polymerase chain reaction was used for betaherpesvirus and polyomavirus quantification purposes after DNA extraction. In total, 50.7% of the 67 analyzed samples were mucocele, 40.3% were adenoma pleomorphic, and 8.9% were mucoepidermoid carcinoma. Overall, 20.9% of samples presented triple-infections with HCMV/HHV-6/HHV-7, whereas 9.0% were co-infections with HCMV/HHV-6 and HCMV/HHV-7. The largest number of co-infections was detected in pleomorphic adenoma cases. All samples tested negative for polyomaviruses, such as BKV and JCV. It was possible to conclude that HCMV can be abundant in salivary gland lesions. A high viral load can be useful to help better understand the etiological role played by viruses in these lesions. A lack of JCV and BKV in the samples analyzed herein does not rule out the involvement of these viruses in one or more salivary gland lesion subtypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Neoplasias de las Glándulas Salivales / Infecciones por Citomegalovirus / Citomegalovirus / Coinfección Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Neoplasias de las Glándulas Salivales / Infecciones por Citomegalovirus / Citomegalovirus / Coinfección Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza