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Semaphorin 4A Maintains Trophoblastic Function via Activating the STAT3 Pathway.
Hou, Taotao; Zhang, Pingping; Tian, Haishen; Luo, Yan; Li, Juan; Zhang, Kuo; Li, Yali.
Afiliación
  • Hou T; Graduate School of Hebei North University, Zhangjiakou 075000, China.
  • Zhang P; Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang 050051, China.
  • Tian H; Department of Gynecology, Tianjin Beichen Hospital, Tianjin 300400, China.
  • Luo Y; Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang 050051, China.
  • Li J; Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang 050051, China.
  • Zhang K; Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang 050051, China.
  • Li Y; Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang 050051, China.
Biomolecules ; 14(7)2024 Jul 10.
Article en En | MEDLINE | ID: mdl-39062540
ABSTRACT
The migration, proliferation, and apoptosis of trophoblastic cells play a crucial role in ensuring the effective preservation of pregnancy at the maternal-fetal interface. Any deviations in the structure and function of these cells might potentially result in the development of numerous pregnancy-related disorders, including missed abortion (MA). This study involved the examination of semaphorin 4A (SEMA4A) expression in missed abortion (n = 18) and normal early pregnancy (n = 18) villus. The findings of this study indicate a statistically significant decrease in the expression of SEMA4A in the villi of individuals diagnosed with missed abortion, as compared to the control group. The results of our vitro study showed that SEMA4A promoted the migration and proliferation of trophoblast cells and inhibited their apoptosis. Subsequent studies have shown that SEMA4A may be involved in regulating p-STAT3/STAT3, MMP9, bcl-2, and BAX levels. In summary, the findings of this study indicate a correlation between the decreased level of SEMA4A in chorionic villi and missed abortion. These results offer novel theoretical insights into the proper implantation and development of SEMA4A embryos at the maternal-fetal interface.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trofoblastos / Transducción de Señal / Apoptosis / Semaforinas / Proliferación Celular / Factor de Transcripción STAT3 Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trofoblastos / Transducción de Señal / Apoptosis / Semaforinas / Proliferación Celular / Factor de Transcripción STAT3 Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza