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AGR2: The Covert Driver and New Dawn of Hepatobiliary and Pancreatic Cancer Treatment.
Qu, Shen; Jia, Weili; Nie, Ye; Shi, Wen; Chen, Chao; Zhao, Zihao; Song, Wenjie.
Afiliación
  • Qu S; Xi'an Medical University, Xi'an 710021, China.
  • Jia W; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
  • Nie Y; Xi'an Medical University, Xi'an 710021, China.
  • Shi W; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
  • Chen C; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
  • Zhao Z; Xi'an Medical University, Xi'an 710021, China.
  • Song W; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Biomolecules ; 14(7)2024 Jun 23.
Article en En | MEDLINE | ID: mdl-39062458
ABSTRACT
The anterior gradient protein 2 (AGR2) plays a crucial role in facilitating the formation of protein disulfide bonds within the endoplasmic reticulum (ER). Research suggests that AGR2 can function as an oncogene, with its heightened expression linked to the advancement of hepatobiliary and pancreatic cancers through invasion and metastasis. Notably, AGR2 not only serves as a pro-oncogenic agent but also as a downstream targeting protein, indirectly fostering cancer progression. This comprehensive review delves into the established functions and expression patterns of AGR2, emphasizing its pivotal role in cancer progression, particularly in hepatobiliary and pancreatic malignancies. Furthermore, AGR2 emerges as a potential cancer prognostic marker and a promising target for immunotherapy, offering novel avenues for the treatment of hepatobiliary and pancreatic cancers and enhancing patient outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Oncogénicas / Mucoproteínas Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Oncogénicas / Mucoproteínas Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza