Your browser doesn't support javascript.
loading
Association of Umbilical Cord Perilipin 2 Levels with Neonatal Anthropometric Measurements in Infants of Diabetic Mothers.
Celik, Kiymet; Ozkan Zarif, Nurten; Ozen Kucukcetin, Ikbal; Arayici, Sema; Kihtir, Zeynep; Unver Tuhan, Hale; Ongun, Hakan.
Afiliación
  • Celik K; Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.
  • Ozkan Zarif N; Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.
  • Ozen Kucukcetin I; Medical Biochemistry Laboratory, Akdeniz University, 07070 Antalya, Turkey.
  • Arayici S; Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.
  • Kihtir Z; Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.
  • Unver Tuhan H; Department of Pediatric Endocrinology, Akdeniz University, 07070 Antalya, Turkey.
  • Ongun H; Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.
Children (Basel) ; 11(7)2024 Jun 25.
Article en En | MEDLINE | ID: mdl-39062220
ABSTRACT

BACKGROUND:

Perilipin 2 (PLIN2) is a protein that contributes to the formation and stability of lipid droplets. It has been associated with the development of several diseases, particularly related to glucose and lipid metabolism. In infants of diabetic mother (IDM), fetal hyperinsulinaemia leads to increased adipose tissue and macrosomia. The aim of this study was to investigate the relationship between PLIN2 levels and anthropometric measurements in the IDM and to investigate the relationship between PLIN2 levels and IGF-1, IGF-2 and leptin levels.

METHODS:

The study group consisted of IDMs, while the control group consisted of infants born to non-diabetic mother, matched for gestational week and gender. Cord blood samples were collected from all patients to determine PLIN2, IGF-1, IGF-2 and leptin levels. Anthropometric measurements were taken for all patients at birth.

RESULTS:

There were no differences between the groups in birth weight, birth length, head circumference and body mass index (BMI), but middle arm circumference, triceps, biceps, subscapular and suprailiac skinfold thickness were significantly higher in the IDM. While PLIN2, IGF-1, IGF-2 and leptin levels were similar between groups, there was a strong correlation between PLIN2 levels and IGF-2 and leptin levels.

CONCLUSIONS:

Even if IDMs were not macrosomic, the presence of high subcutaneous adipose tissue was not associated with PLIN2.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Children (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Children (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza