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Nocturnal Glucose Profile According to Timing of Dinner Rapid Insulin and Basal and Rapid Insulin Type: An Insulclock® Connected Insulin Cap-Based Real-World Study.
Gómez-Peralta, Fernando; Valledor, Xoan; Abreu, Cristina; Fernández-Rubio, Elsa; Cotovad, Laura; Pujante, Pedro; Azriel, Sharona; Pérez-González, Jesús; Vallejo, Alba; Ruiz-Valdepeñas, Luis; Corcoy, Rosa.
Afiliación
  • Gómez-Peralta F; Endocrinology and Nutrition Unit, Hospital General de Segovia, Luis Erik Clavería Neurólogo S.N Street, 40002 Segovia, Spain.
  • Valledor X; Research and Development Unit, Insulcloud S.L., 28020 Madrid, Spain.
  • Abreu C; Endocrinology and Nutrition Unit, Hospital General de Segovia, Luis Erik Clavería Neurólogo S.N Street, 40002 Segovia, Spain.
  • Fernández-Rubio E; Endocrinology and Nutrition Service, Cruces University Hospital, 48903 Barakaldo, Spain.
  • Cotovad L; Endocrinology and Nutrition Service, Hospital Arquitecto Marcide, 15405 Ferrol, Spain.
  • Pujante P; Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
  • Azriel S; Endocrinology and Nutrition Service, Hospital Universitario Infanta Sofía, 28702 San Sebastián De Los Reyes, Spain.
  • Pérez-González J; Research and Development Unit, Insulcloud S.L., 28020 Madrid, Spain.
  • Vallejo A; Research and Development Unit, Insulcloud S.L., 28020 Madrid, Spain.
  • Ruiz-Valdepeñas L; Research and Development Unit, Insulcloud S.L., 28020 Madrid, Spain.
  • Corcoy R; Endocrinology and Nutrition Service, Hospital de la Santa Creu i Sant Pau, Institut de Recerca, 08041 Barcelona, Spain.
Biomedicines ; 12(7)2024 Jul 18.
Article en En | MEDLINE | ID: mdl-39062173
ABSTRACT

BACKGROUND:

A study to assess the glucose levels of people with type 1 diabetes (T1D) overnight, based on the insulin type and timing.

METHODS:

A real-world, retrospective study of T1D, using multiple daily insulin injections. Continuous glucose monitoring and insulin injection data were collected for ten hours after dinner using the Insulclock® connected cap. Meal events were identified using the ROC detection methodology. The timing of the rapid insulin, second injections, and the type of insulin analogs used, were evaluated.

RESULTS:

The nocturnal profiles (n = 775, 49 subjects) were analyzed. A higher glucose AUC of over 180 mg/dL was observed in subjects with delayed injections (number; %; mg/dL × h) -45-15 min (n = 136; 17.5%, 175.9 ± 271.0); -15-0 min (n = 231; 29.8%, 164.0 ± 2 37.1); 0 + 45 min (n = 408; 52.6%, 203.6 ± 260.9), (p = 0.049). The use of ultrarapid insulin (FiAsp®) (URI) vs. rapid insulin (RI) analogs was associated with less hypoglycemia events (7.1 vs. 13.6%; p = 0.005) and TBR70 (1.7 ± 6.9 vs. 4.6 ± 13.9%; p = 0.003). Users of glargine U300 vs. degludec had a higher TIR (70.7 vs. 58.5%) (adjusted R-squared 0.22, p < 0.001). The use of a correction injection (n = 144, 18.6%) was associated with a higher number of hypoglycemia events (18.1 vs. 9.5%; p = 0.003), TBR70 (5.5 ± 14.2 vs. 3.0 ± 11.1%; p = 0.003), a glucose AUC of over 180 mg/dL (226.1 ± 257.8 vs. 178.0 ± 255.3 mg/dL × h; p = 0.001), and a lower TIR (56.0 ± 27.4 vs. 62.7 ± 29.6 mg/dL × h; p = 0.004).

CONCLUSION:

The dinner rapid insulin timing, insulin type, and the use of correction injections affect the nocturnal glucose profile in T1D.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza