Your browser doesn't support javascript.
loading
Three-Dimensional-Printed Modular Titanium Alloy Plates for Osteosynthesis of the Jawbone.
Dobrzynski, Maciej; Szymonowicz, Maria; Nowicka, Joanna; Pajaczkowska, Magdalena; Nikodem, Anna; Kuropka, Piotr; Wawrzynska, Magdalena; Rusak, Agnieszka.
Afiliación
  • Dobrzynski M; Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
  • Szymonowicz M; Pre-Clinical Research Centre, Wroclaw Medical University, 50-368 Wroclaw, Poland.
  • Nowicka J; Department and Division of Microbiology, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.
  • Pajaczkowska M; Department and Division of Microbiology, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.
  • Nikodem A; Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, 50-371 Wroclaw, Poland.
  • Kuropka P; Division of Histology and Embryology, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland.
  • Wawrzynska M; Pre-Clinical Research Centre, Wroclaw Medical University, 50-368 Wroclaw, Poland.
  • Rusak A; Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Biomedicines ; 12(7)2024 Jul 02.
Article en En | MEDLINE | ID: mdl-39062039
ABSTRACT
BACKGROUNDS The titanium-aluminum-vanadium alloy (Ti-6Al-4V) is frequently used in implantology due to its biocompatibility. The use of 3D printing enables the mechanical modification of implant structures and the adaptation of their shape to the specific needs of individual patients.

METHODS:

The titanium alloy plates were designed using the 3D CAD method and printed using a 3D SLM printer. Qualitative tests were performed on the material surface using a microcomputed tomography scanner. The cytotoxicity of the modular titanium plates was investigated using the MTT assay on the L929 cell line and in direct contact with Balb/3T3 cells. Cell adhesion to the material surface was evaluated with hFOB1.19 human osteoblasts. Microbial biofilm formation was investigated on strains of Lactobacillus rhamnosus, Staphylococcus epidermidis, Streptococcus mutans and Candida albicans using the TTC test and scanning electron microscopy (SEM).

RESULTS:

The surface analysis showed the hydrophobic nature of the implant. The study showed that the titanium plates had no cytotoxic properties. In addition, the material surface showed favorable properties for osteoblast adhesion. Among the microorganisms tested, the strains of S. mutans and S. epidermidis showed the highest adhesion capacity to the plate surface, while the fungus C. albicans showed the lowest adhesion capacity.

CONCLUSIONS:

The manufactured modular plates have properties that are advantageous for the implantation and reduction in selected forms of microbial biofilm. Three-dimensional-printed modular titanium plates were investigated in this study and revealed the potential clinical application of this type of materials, regarding lack of cytotoxicity, high adhesion properties for osteoblasts and reduction in biofilm formation. The 3D CAD method allows us to personalise the shape of implants for individual patients.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza