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High-Density Lipoprotein Correlates with Cognitive Functioning in Schizophrenic Women.
Staniek, Maria; Kapelski, Pawel; Zakowicz, Przemyslaw; Rajewska-Rager, Aleksandra; Wasicka-Przewozna, Karolina; Skibinska, Maria.
Afiliación
  • Staniek M; Independent Researcher, 60-806 Poznan, Poland.
  • Kapelski P; Department of Psychiatric Genetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
  • Zakowicz P; Collegium Medicum, University of Zielona Góra, 65-417 Zielona Gora, Poland.
  • Rajewska-Rager A; Department of Psychiatric Genetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
  • Wasicka-Przewozna K; Department of Psychiatric Genetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
  • Skibinska M; Department of Psychiatric Genetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
Brain Sci ; 14(7)2024 Jul 12.
Article en En | MEDLINE | ID: mdl-39061439
ABSTRACT
(1)

Background:

Schizophrenia is a chronic and progressive neuropsychiatric illness. Apart from positive and negative symptoms, 98% of the population diagnosed with schizophrenia have impaired cognitive functioning, which significantly influences the quality of life. The correlation between lipids and cognitive functioning has been well established. Our study aimed to investigate correlations between cognitive functions, the severity of schizophrenia symptoms, and lipid profiles. (2)

Methods:

Fifty-two women diagnosed with schizophrenia participated in this study. Cognitive functioning was measured using the Wisconsin Card Sorting Test (WCST). The Positive and Negative Symptom Scale (PANSS) was used. The serum lipid profile, including low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), and triglycerides was measured. (3)

Results:

Better cognitive functions were associated with normal HDL levels, while low HDL levels correlated with worse WSCT scores. Only the PANSS negative subscale showed a correlation with HDL levels. Correlations with chronicity of schizophrenia and the patient's age with poorer cognitive functions, but not with symptom severity, were detected. Early/late age at onset did not influence WSCT scores. (4)

Conclusions:

Our results suggest high HDL levels might be a protective factor against cognitive impairment. The influences of age and illness duration also play a vital role in cognitive performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza