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Non-Dominant Hemisphere Excitability Is Unaffected during and after Transcranial Direct Current Stimulation of the Dominant Hemisphere.
Wilkins, Erik W; Young, Richard J; Houston, Daniel; Kawana, Eric; Lopez Mora, Edgar; Sunkara, Meghana S; Riley, Zachary A; Poston, Brach.
Afiliación
  • Wilkins EW; Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV 89154, USA.
  • Young RJ; Interdisciplinary Ph.D. Program in Neuroscience, University of Nevada, Las Vegas, NV 89154, USA.
  • Houston D; Interdisciplinary Ph.D. Program in Neuroscience, University of Nevada, Las Vegas, NV 89154, USA.
  • Kawana E; School of Medicine, University of Nevada, Las Vegas, NV 89154, USA.
  • Lopez Mora E; School of Medicine, University of Nevada, Las Vegas, NV 89154, USA.
  • Sunkara MS; School of Medicine, University of Nevada, Las Vegas, NV 89154, USA.
  • Riley ZA; Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA.
  • Poston B; Department of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Brain Sci ; 14(7)2024 Jul 12.
Article en En | MEDLINE | ID: mdl-39061434
ABSTRACT
Transcranial direct current stimulation (tDCS) increases primary motor cortex (M1) excitability and improves motor performance when applied unilaterally to the dominant hemisphere. However, the influence of tDCS on contralateral M1 excitability both during and after application has not been quantified. The purpose was to determine the influence of tDCS applied to the dominant M1 on the excitability of the contralateral non-dominant M1. This study employed a double-blind, randomized, SHAM-controlled, within-subject crossover experimental design. Eighteen young adults performed two experimental sessions (tDCS, SHAM) in counterbalanced order separated by a one-week washout. Transcranial magnetic stimulation (TMS) was used to quantify the excitability of the contralateral M1 to which anodal tDCS was applied for 20 min with a current strength of 1 mA. Motor evoked potential (MEP) amplitudes were assessed in 5 TMS test blocks (Pre, D5, D10, D15, and Post). The Pre and Post TMS test blocks were performed immediately before and after tDCS application, whereas the TMS test blocks performed during tDCS were completed at the 5, 10, and 15 min stimulation timepoints. MEPs were analyzed with a 2 condition (tDCS, SHAM) × 5 test (Pre, D5, D10, D15, Post) within-subject ANOVA. The main effect for condition (p = 0.213), the main effect for test (p = 0.502), and the condition × test interaction (p = 0.860) were all not statistically significant. These results indicate that tDCS does not modulate contralateral M1 excitability during or immediately after application, at least under the current set of common tDCS parameters of stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza