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Hospitalized COVID-19 Patients with Urinary Tract Infection in Iran: Candida Species Distribution and Antifungal Susceptibility Patterns.
Shiyadeh, Zeinab Soleimani; Farahyar, Shirin; Vahedi Larijani, Laleh; Beardsley, Justin; Nouri, Noura; Mahmoudi, Shahram; Roudbar Mohammadi, Shahla; Rodrigues, Célia Fortuna; Roudbary, Maryam.
Afiliación
  • Shiyadeh ZS; Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
  • Farahyar S; Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
  • Vahedi Larijani L; Microbial Biotechnology Research Center (MBiRC), School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
  • Beardsley J; Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48175-866, Iran.
  • Nouri N; Sydney Infectious Diseases Institute, University of Sydney, Sydney, NSW 2145, Australia.
  • Mahmoudi S; Westmead Hospital, NSW Health, Sydney, NSW 2145, Australia.
  • Roudbar Mohammadi S; Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115111, Iran.
  • Rodrigues CF; Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
  • Roudbary M; Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115111, Iran.
Antibiotics (Basel) ; 13(7)2024 Jul 08.
Article en En | MEDLINE | ID: mdl-39061315
ABSTRACT
Candida species, typically part of the human skin and mucous membrane flora, can cause opportunistic fungal infections, notably urinary tract infections (UTIs), which are on the rise among hospitalized COVID-19 patients. The lack of understanding of UTIs in this population, coupled with the emergence of multidrug-resistant strains, poses significant challenges for effective treatment and further investigations. In this study, urine samples were collected from 70 COVID-19 patients with UTIs in sterile containers for microbiology examination. After microscopic observation, the isolates were identified both by phenotypic and molecular techniques such as multiplex PCR. Antifungal susceptibility testing (AFST) against fluconazole (Flu), itraconazole (Itr), and amphotericin B (AMB) was performed according to CLSI M27/S4 standard methods, with the frequency of isolates including Candida albicans (n = 20, 51.3%), Candida tropicalis (n = 15, 38.4%), Nakaseomyces glabrata (previously Candida glabrata) (n = 2, 5.1%), Pichia kudriavzevii (previously Candida krusei), and Candida parapsilosis (n = 1, 2.5%). All isolates of C. albicans, C. tropicalis, C. glabrata, and C. parapsilosis were sensitive to amphotericin B, while C. kruzei was resistant to AMB. Around 70% of C. albicans isolates were sensitive to Flu; 20% of C. tropicalis were resistant to itraconazole, while 33% were resistant to fluconazole. C. albicans and C. tropicalis were the main causes of candiduria in infected cases and both Flu and AMB showed good results in AFST in these species. Performing drug susceptibility testing for clinical isolates of Candida spp. provided guidance for appropriate management and control, and timely antifungal treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Suiza