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New Fe3O4-Based Coatings with Enhanced Anti-Biofilm Activity for Medical Devices.
Pirușca, Ioana Adelina; Balaure, Paul Catalin; Grumezescu, Valentina; Irimiciuc, Stefan-Andrei; Oprea, Ovidiu-Cristian; Bîrca, Alexandra Catalina; Vasile, Bogdan; Holban, Alina Maria; Voinea, Ionela C; Stan, Miruna S; Trușca, Roxana; Grumezescu, Alexandru Mihai; Croitoru, George-Alexandru.
Afiliación
  • Pirușca IA; Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Balaure PC; Department of Organic Chemistry, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Grumezescu V; Lasers Department, National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania.
  • Irimiciuc SA; Lasers Department, National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania.
  • Oprea OC; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Bîrca AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Vasile B; Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Holban AM; Microbiology and Immunology Department, Faculty of Biology, University of Bucharest, 77206 Bucharest, Romania.
  • Voinea IC; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.
  • Stan MS; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.
  • Trușca R; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.
  • Grumezescu AM; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.
  • Croitoru GA; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.
Antibiotics (Basel) ; 13(7)2024 Jul 07.
Article en En | MEDLINE | ID: mdl-39061313
ABSTRACT
With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause of morbidity and mortality. Herein, we present the fabrication, characterization, and in vitro evaluation of biocompatibility and anti-biofilm properties of new coatings based on Fe3O4 nanoparticles (NPs) loaded with usnic acid (UA) and ceftriaxone (CEF). Sodium lauryl sulfate (SLS) was employed as a stabilizer and modulator of the polarity, dispersibility, shape, and anti-biofilm properties of the magnetite nanoparticles. The resulting Fe3O4 functionalized NPs, namely Fe3O4@SLS, Fe3O4@SLS/UA, and Fe3O4@SLS/CEF, respectively, were prepared by co-precipitation method and fully characterized by XRD, TEM, SAED, SEM, FTIR, and TGA. They were further used to produce nanostructured coatings by matrix-assisted pulsed laser evaporation (MAPLE) technique. The biocompatibility of the coatings was assessed by measuring the cell viability, lactate dehydrogenase release, and nitric oxide level in the culture medium and by evaluating the actin cytoskeleton morphology of murine pre-osteoblasts. All prepared nanostructured coatings exhibited good biocompatibility. Biofilm growth inhibition ability was tested at 24 h and 48 h against Staphylococcus aureus and Pseudomonas aeruginosa as representative models for Gram-positive and Gram-negative bacteria. The coatings demonstrated good biocompatibility, promoting osteoblast adhesion, migration, and growth without significant impact on cell viability or morphology, highlighting their potential for developing safe and effective antibacterial surfaces.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza