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Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024.
Saito, Takashi; Mizumoto, Masashi; Oshiro, Yoshiko; Shimizu, Shosei; Li, Yinuo; Nakamura, Masatoshi; Hosaka, Sho; Nakai, Kei; Iizumi, Takashi; Inaba, Masako; Fukushima, Hiroko; Suzuki, Ryoko; Maruo, Kazushi; Sakurai, Hideyuki.
Afiliación
  • Saito T; Department of Radiation Oncology, University of Tsukuba, Tsukuba 305-8576, Ibaraki, Japan.
  • Mizumoto M; Department of Radiation Oncology, University of Tsukuba, Tsukuba 305-8576, Ibaraki, Japan.
  • Oshiro Y; Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba 305-8558, Ibaraki, Japan.
  • Shimizu S; Department of Pediatric Radiation Therapy Center/Pediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou 072750, China.
  • Li Y; Department of Radiation Oncology, University of Tsukuba, Tsukuba 305-8576, Ibaraki, Japan.
  • Nakamura M; Department of Radiation Oncology, University of Tsukuba, Tsukuba 305-8576, Ibaraki, Japan.
  • Hosaka S; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba 305-8575, Ibaraki, Japan.
  • Nakai K; Department of Radiation Oncology, University of Tsukuba, Tsukuba 305-8576, Ibaraki, Japan.
  • Iizumi T; Department of Radiation Oncology, University of Tsukuba, Tsukuba 305-8576, Ibaraki, Japan.
  • Inaba M; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba 305-8575, Ibaraki, Japan.
  • Fukushima H; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba 305-8575, Ibaraki, Japan.
  • Suzuki R; Department of Child Health, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan.
  • Maruo K; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba 305-8575, Ibaraki, Japan.
  • Sakurai H; Department of Child Health, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan.
Cancers (Basel) ; 16(14)2024 Jul 17.
Article en En | MEDLINE | ID: mdl-39061207
ABSTRACT
[Objective] The aim of this study was to compare the efficacy of particle beam therapy (PT) with photon radiotherapy (RT) for treatment of skull base chordoma. [Methods] A systematic review was conducted for skull base chordoma treated with PT or photon RT reported from 1990 to 2022. Data were extracted for overall survival (OS) and progression-free survival (PFS), late adverse events, age, gender, gross total resection (GTR) rates, tumor volume, total irradiation dose, and treatment modality. Random-effects meta-regression analysis with the treatment modality as an explanatory variable was performed for each outcome to compare the modalities. [Results] A meta-analysis of 30 selected articles found 3- and 5-year OS rates for PT vs. photon RT or combined photon RT/proton beam therapy (PBT) of 90.8% (95% CI 87.4-93.3%) vs. 89.5% (95% CI 83.0-93.6%), p = 0.6543; 80.0% (95% CI 75.7-83.6%) vs. 89.5% (95% CI 83.0-93.6%), p = 0.6787. The 5-year PFS rates for PT vs. photon RT or photon RT/PBT were 67.8% (95% CI 56.5-76.7%) vs. 40.2% (95% CI 31.6-48.7%), p = 0.0004. A random-effects model revealed that the treatment modality (PT vs. photon RT or photon RT/PBT) was not a significant factor for 3-year OS (p = 0.42) and 5-year OS (p = 0.11), but was a significant factor for 5-year PFS (p < 0.0001). The rates of brain necrosis were 8-50% after PT and 0-4% after photon RT or photon RT/PBT. [Conclusion] This study shows that PT results in higher PFS compared to photon RT for skull base chordoma, but that there is a tendency for a higher incidence of brain necrosis with PT. Publication and analysis of further studies is needed to validate these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza