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Prognostic and Therapeutic Implications of Cell Division Cycle 20 Homolog in Breast Cancer.
Messeha, Samia S; Zarmouh, Najla O; Maku, Henrietta; Gendy, Sherif; Yedjou, Clement G; Elhag, Rashid; Latinwo, Lekan; Odewumi, Caroline; Soliman, Karam F A.
Afiliación
  • Messeha SS; College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA.
  • Zarmouh NO; College of Pharmacy & Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, New Pharmacy Building, 1520 ML King Blvd, Tallahassee, FL 32307, USA.
  • Maku H; Faculty of Medical Technology-Misrata, Libyan Ministry of Technical & Vocational Education, Misrata LY72, Libya.
  • Gendy S; Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
  • Yedjou CG; School of Allied Health Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
  • Elhag R; College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA.
  • Latinwo L; College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA.
  • Odewumi C; College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA.
  • Soliman KFA; College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA.
Cancers (Basel) ; 16(14)2024 Jul 15.
Article en En | MEDLINE | ID: mdl-39061186
ABSTRACT
Cell division cycle 20 homolog (CDC20) is a well-known regulator of cell cycle progression. Abnormal expression of CDC20 leads to mitotic defects, which play a significant role in cancer development. In breast cancer (BC), CDC20 has been identified as a biomarker that has been linked to poor patient outcomes. In this study, we investigated the association of CDC20 with BC prognosis and immune cell infiltration by using multiple online databases, including UALCAN, KM plotter, TIMER2.0, HPA, TNM-plot, bc-GenExMiner, LinkedOmics, STRING, and GEPIA. The results demonstrate that BC patients have an elevated CDC20 expression in tumor tissues compared with the adjacent normal tissue. In addition, BC patients with overexpressed CDC20 had a median survival of 63.6 months compared to 169.2 months in patients with low CDC20 expression. Prognostic analysis of the examined data indicated that elevated expression of CDC20 was associated with poor prognosis and a reduction of overall survival in BC patients. These findings were even more prevalent in chemoresistance triple-negative breast cancer (TNBC) patients. Furthermore, the Gene Set Enrichment Analysis tool indicated that CDC20 regulates BC cells' cell cycle and apoptosis. CDC20 also significantly correlates with increased infiltrating B cells, CD4+ T cells, neutrophils, and dendritic cells in BC. In conclusion, the findings of this study suggest that CDC20 may be involved in immunomodulating the tumor microenvironment and provide evidence that CDC20 inhibition may serve as a potential therapeutic approach for the treatment of BC patients. In addition, the data indicates that CDC20 can be a reliable prognostic biomarker for BC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza