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Longitudinal evaluation of polyneuropathy in Parkinson's disease.
Kwon, Eun Hae; Bieber, Antonia; Schülken, Paula; Müller, Katharina; Kühn, Eva; Averdunk, Paulina; Kools, Saskia; Hilker, Lovis; Kirchgässler, András; Ebner, Lea; Ortmann, Louisa; Basner, Louisa; Steininger, Julia; Kleinz, Teresa; Motte, Jeremias; Fisse, Anna Lena; Schneider-Gold, Christiane; Gold, Ralf; Scherbaum, Raphael; Muhlack, Siegfried; Tönges, Lars; Pitarokoili, Kalliopi.
Afiliación
  • Kwon EH; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany. eunhae.kwon@rub.de.
  • Bieber A; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Schülken P; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Müller K; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Kühn E; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Averdunk P; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Kools S; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Hilker L; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Kirchgässler A; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Ebner L; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Ortmann L; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Basner L; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Steininger J; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Kleinz T; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Motte J; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Fisse AL; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Schneider-Gold C; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Gold R; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Scherbaum R; Neurodegeneration Research, Centre for Protein Diagnostics (ProDi), Ruhr University, 44791, Bochum, Germany.
  • Muhlack S; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Tönges L; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Pitarokoili K; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
J Neurol ; 271(9): 6136-6146, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39060619
ABSTRACT

BACKGROUND:

Increasing evidence indicates a higher prevalence of polyneuropathy (PNP) in Parkinson's disease (PD). However, the involvement of large fiber neuropathy in PD still remains poorly understood. Given the lack of longitudinal data, we investigated the course of PNP associated with PD.

METHODS:

In total, 41 PD patients underwent comprehensive clinical evaluation including motor and non-motor assessments as well as nerve conduction studies at baseline and at 2 years of follow-up. The definition of PNP was based on electrophysiological standard criteria. Common causes of PNP were excluded.

RESULTS:

At baseline, PNP was diagnosed in 65.85% of PD patients via electroneurography. Patients with PNP presented with higher age (p = 0.019) and PD motor symptom severity (UPDRS III; p < 0.001). Over the course of 2 years, PNP deteriorated in 21.95% of cases, and 26.83% remained without PNP. Deterioration of nerve amplitude was most prevalent in the median sensory nerve affecting 57.58% of all PD cases with an overall reduction of median sensory nerve amplitude of 45.0%. With regard to PD phenotype, PNP progression was observed in 33.33% of the tremor dominant and 23.81% of the postural instability/gait difficulties subtype. Decrease of sural nerve amplitude correlated with lower quality of life (PDQ-39, p = 0.037) and worse cognitive status at baseline (MoCA, p = 0.042).

CONCLUSION:

The study confirms the high PNP rate in PD, and demonstrates a significant electrophysiological progression also involving nerves of the upper extremities. Longitudinal studies with larger cohorts are urgently needed and should elucidate the link between PD and PNP with the underlying pathomechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Polineuropatías / Progresión de la Enfermedad / Conducción Nerviosa Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Polineuropatías / Progresión de la Enfermedad / Conducción Nerviosa Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania