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The use of stem cells in treating xerostomia: a systematic review.
Aritzi, Ioanna; Konstantinidis, Iordanis; Kyriakidou, Artemis; Garefis, Konstantinos; Sideris, Giorgos; Delides, Alexander.
Afiliación
  • Aritzi I; Otorhinolaryngology- Head and Neck Department, 'Saint Savvas' General Anticancer Oncology Hospital of Athens, Alexandras Avenue 171, 11522, Athens, Greece. ioannaaritzi@gmail.com.
  • Konstantinidis I; Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. ioannaaritzi@gmail.com.
  • Kyriakidou A; Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Garefis K; Second Academic Otorhinolaryngology-Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
  • Sideris G; Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Delides A; Second Academic Otorhinolaryngology-Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Eur Arch Otorhinolaryngol ; 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-39060406
ABSTRACT

INTRODUCTION:

The complex nature of xerostomia prevents the establishment of a definite cure. Recently, research has pivoted towards stem cell transplantation for glandular reconstruction. The aim of this study is to provide an updated review of the existing research, to highlight the encountered challenges and research pathways, potentially enhancing the therapeutic applications of stem cell transplantation.

METHODS:

This is a systematic review according to PRISMA guidelines, using the following databases PubMed (PMC), PMC Europe, Scopus, Medline, Research Gate, Elsevier. The main question was whether stem cell therapies can contribute to the treatment of xerostomia.

RESULTS:

19 of 226 publications met the criteria for this review, including 'in vivo', 'in vitro' studies and clinical trials. All 19 studies described thoroughly the stem cell source and the transplantation method, and documented results based on analytical and statistical methods of confirmation. Data show that the various sources of stem cells play a significant role, with bone marrow or adipose tissue-derived pluripotent blasts being the most utilized. Human transplants in mice have also been accepted and reversed hyposalivation. The effects have been beneficial especially in models undergone radiotherapy (IR) or exhibit Sjogren Syndrome-like symptoms (SS), suggesting that with appropriate treatment and enrichment techniques, stem cell transplantation seems effective regardless of the cause of the disorder. Extracts and co-cultures of gland and stem cells also seem to improve gland function.

CONCLUSION:

Although in its initial stages, the use of stem cells seems to be a promising therapy to alleviate xerostomia regardless of its cause.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania