Loss of ARID1A 'loops' in STING.

Goswami, Sangeeta; Sharma, Padmanee

Goswami, Sangeeta; Sharma, Padmanee.

Afiliación

Goswami S; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sharma P; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: padsharma@mdanderson.org.

Trends Immunol ; 45(8): 568-570, 2024 Aug.

Article en En | MEDLINE | ID: mdl-39060141

ABSTRACT

ABSTRACT

In a recent article, Maxwell et al. report that loss of tumor cell-specific AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, triggers antitumor immunity via R-loop-mediated upregulation of the type-I interferon (IFN) pathway. These recent findings uncover a molecular mechanism underlying improved responses to immune checkpoint therapy (ICT) seen in patients harboring an ARID1A loss-of-function mutation.

Asunto(s)

Proteínas de Unión al ADN; Proteínas de la Membrana; Neoplasias; Factores de Transcripción; Humanos; Factores de Transcripción/metabolismo; Factores de Transcripción/genética; Proteínas de Unión al ADN/metabolismo; Proteínas de Unión al ADN/genética; Neoplasias/inmunología; Neoplasias/genética; Animales; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Mutación; Transducción de Señal; Interferón Tipo I/metabolismo; Interferón Tipo I/inmunología; Ensamble y Desensamble de Cromatina

Palabras clave

ARID1A; Interferon; R-loop; STING; anti-tumor immunity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas de Unión al ADN / Proteínas de la Membrana / Neoplasias Límite: Animals / Humans Idioma: En Revista: Trends Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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