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Novel antibacterial orthodontic elastomeric ligature with oral biofilm-regulatory ability to prevent enamel demineralization.
Bian, Ce; Lyu, Menghao; Zhu, Mengyao; Liu, Miao; Xie, Xianju; Weir, Michael D; Hack, Gary D; Masri, Radi; Zhang, Ke; Bai, Yuxing; Xu, Hockin H K; Zhang, Ning.
Afiliación
  • Bian C; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Lyu M; Department of Periodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Zhu M; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Liu M; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Xie X; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Weir MD; Department of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
  • Hack GD; Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
  • Masri R; Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
  • Zhang K; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Bai Y; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China.
  • Xu HHK; Department of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
  • Zhang N; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China. Electronic address: dentistzhang112@163.com.
Dent Mater ; 40(10): 1534-1545, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39060129
ABSTRACT

OBJECTIVES:

To synthesize a novel antibacterial orthodontic elastomeric ligature incorporating dimethylaminohexadecyl methacrylate (DMAHDM) for the first time to prevent enamel demineralization during orthodontic therapy.

METHODS:

Various mass fractions of DMAHDM (ranging from 0 % to 20 %) were grafted onto commercial elastomeric ligatures using an ultraviolet photochemical grafting method and were characterized. The optimal DMAHDM concentration was determined based on biocompatibility and mechanical properties, and the antibacterial efficacy was evaluated in a whole-plaque biofilm model. TaqMan real-time polymerase chain reaction and fluorescence in situ hybridization were used to assess the microbial regulatory ability of the multispecies biofilms. Furthermore, an in vitro tooth demineralization model was established to explore its preventive effects on enamel demineralization. Statistical analysis involved a one-way analysis of variance and LSD post hoc tests at a significance level of 0.05.

RESULTS:

The elastomeric ligature containing 2 % mass fraction of DMAHDM exhibited excellent mechanical properties, favorable biocompatibility, and the most effective antibacterial ability against microorganisms, which decreased by almost two logarithms (P < 0.05). It significantly reduced the proportion of Streptococcus mutans in the multispecies plaque biofilm by 25 % at 72 h, leading to an enhanced biofilm microenvironment. Moreover, the novel elastomeric ligature demonstrated an obvious preventive effect on enamel demineralization, with an elastic modulus 30 % higher and hardness 62 % higher than those of the control group within 3 months (P < 0.05).

SIGNIFICANCE:

The integration of DMAHDM with an elastomeric ligature holds significant promise for regulating biofilms and preventing enamel demineralization in orthodontic applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desmineralización Dental / Biopelículas / Elastómeros / Metacrilatos / Antibacterianos Idioma: En Revista: Dent Mater Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desmineralización Dental / Biopelículas / Elastómeros / Metacrilatos / Antibacterianos Idioma: En Revista: Dent Mater Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido