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Neural Substrates of Emotion Processing and Cognitive Control Over Emotion in Youth Anxiety: An RDoC-Informed Study Across the Clinical to Nonclinical Continuum of Severity.
Díaz, Dana E; Russman Block, Stefanie R; Becker, Hannah C; Phan, K Luan; Monk, Christopher S; Fitzgerald, Kate D.
Afiliación
  • Díaz DE; Columbia University Irving Medical Center, New York, New York. Electronic address: dana.glenn@nyspi.columbia.edu.
  • Russman Block SR; University of Michigan, Ann Arbor, Michigan.
  • Becker HC; University of Michigan, Ann Arbor, Michigan.
  • Phan KL; Ohio State University, Columbus, Ohio.
  • Monk CS; University of Michigan, Ann Arbor.
  • Fitzgerald KD; Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
J Am Acad Child Adolesc Psychiatry ; 2024 Jul 24.
Article en En | MEDLINE | ID: mdl-39059719
ABSTRACT

OBJECTIVE:

Clinically anxious youth are hypervigilant to emotional stimuli and display difficulty shifting attention from emotional to nonemotional stimuli, suggesting impairments in cognitive control over emotion. However, it is unknown whether the neural substrates of such biases vary across the clinical-to-nonclinical range of anxiety or by age.

METHOD:

Youth aged 7 to 17 years with clinical anxiety (n = 119) or without an anxiety diagnosis (n = 41) matched emotional faces or matched shapes flanked by emotional face distractors during magnetic resonance imaging, probing emotion processing and cognitive control over emotion, respectively. Building from the National Institute of Mental Health Research Domain Criteria (RDoC) framework, clinically anxious youth were sampled across diagnostic categories, and non-clinically affected youth were sampled across minimal-to-subclinical severity.

RESULTS:

Across both conditions, anxiety severity was associated with hyperactivation in the right inferior parietal lobe, a substrate of hypervigilance. Brain-anxiety associations were also differentiated by attentional state; anxiety severity was associated with greater left ventrolateral prefrontal cortex activation during emotion processing (face matching) and greater activation in the left posterior superior temporal sulcus and temporoparietal junction (and slower responses) during cognitive control over emotion (shape matching). Age also moderated associations between anxiety and cognitive control over emotion, such that anxiety was associated with greater right thalamus and bilateral posterior cingulate cortex activation for children at younger and mean ages, but not for older youth.

CONCLUSION:

Aberrant function in brain regions implicated in stimulus-driven attention to emotional distractors may contribute to anxiety in youth. Results support the potential utility of attention modulation interventions for anxiety that are tailored to developmental stage. CLINICAL TRIAL REGISTRATION INFORMATION Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety; https//clinicaltrials.gov; NCT02810171.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Acad Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Acad Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos