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Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report.
Susic, Tamara; Miler, Marijana; Nikolac Gabaj, Nora; Tesija Kuna, Andrea; Kordic, Kresimir; Ilic, Vedrana; Vinter, Ozren.
Afiliación
  • Susic T; Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
  • Miler M; Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia. Electronic address: marijana.miler@kbcsm.hr.
  • Nikolac Gabaj N; Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
  • Tesija Kuna A; Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia; Catholic University of Croatia, Zagreb, Croatia.
  • Kordic K; Catholic University of Croatia, Zagreb, Croatia; Department of Cardiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
  • Ilic V; Department of Cardiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
  • Vinter O; Catholic University of Croatia, Zagreb, Croatia; Department of Cardiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
Clin Biochem ; 131-132: 110802, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39059607
ABSTRACT
Elevated troponin levels are often indicative of various cardiac diseases; however, analytical interference can lead to false positive troponin concentrations. We present the case of a 48-year-old female patient with persistently falsely elevated high sensitivity troponin I (hsTnI) probably caused by the presence of macrotroponin. Laboratory testing included determination of hsTnI using various analytical methods, serial dilutions and determination of heterophilic antibodies and other autoimmune antibodies. Only precipitation with polyethylene glycol (PEG) indicated the presence of an interference by causing a significant decrease in hsTnI concentration. Our results suggest that the falsely elevated hsTnI concentration could be due to interference with the macrotroponin complex.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Troponina I Límite: Female / Humans / Middle aged Idioma: En Revista: Clin Biochem Año: 2024 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Troponina I Límite: Female / Humans / Middle aged Idioma: En Revista: Clin Biochem Año: 2024 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Estados Unidos