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Diabetes mellitus-Progress and opportunities in the evolving epidemic.
Abel, E Dale; Gloyn, Anna L; Evans-Molina, Carmella; Joseph, Joshua J; Misra, Shivani; Pajvani, Utpal B; Simcox, Judith; Susztak, Katalin; Drucker, Daniel J.
Afiliación
  • Abel ED; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address: domchair_daleabel@mednet.ucla.edu.
  • Gloyn AL; Department of Pediatrics, Division of Endocrinology & Diabetes, Department of Genetics, Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA.
  • Evans-Molina C; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Joseph JJ; Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Columbus, OH, USA.
  • Misra S; Department of Metabolism, Digestion and Reproduction, Imperial College London, and Imperial College NHS Trust, London, UK.
  • Pajvani UB; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
  • Simcox J; Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Susztak K; Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
  • Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.
Cell ; 187(15): 3789-3820, 2024 Jul 25.
Article en En | MEDLINE | ID: mdl-39059357
ABSTRACT
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads to complications that reduce quality of life and increase mortality. Diabetes pathophysiology includes dysfunction of beta cells, adipose tissue, skeletal muscle, and liver. Type 1 diabetes (T1D) results from immune-mediated beta cell destruction. The more prevalent type 2 diabetes (T2D) is a heterogeneous disorder characterized by varying degrees of beta cell dysfunction in concert with insulin resistance. The strong association between obesity and T2D involves pathways regulated by the central nervous system governing food intake and energy expenditure, integrating inputs from peripheral organs and the environment. The risk of developing diabetes or its complications represents interactions between genetic susceptibility and environmental factors, including the availability of nutritious food and other social determinants of health. This perspective reviews recent advances in understanding the pathophysiology and treatment of diabetes and its complications, which could alter the course of this prevalent disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 Límite: Animals / Humans Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 Límite: Animals / Humans Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos