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Endocrine fibroblast growth factors in domestic animals.
Brinker, Emily J; Hardcastle, Michael R; Dittmer, Keren E; Graff, Emily C.
Afiliación
  • Brinker EJ; Department of Pathobiology, College of Veterinary Medicine, 166 Greene Hall, Auburn University, AL, USA 36849; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA, USA 01536.
  • Hardcastle MR; IDEXX Laboratories Pty. Ltd., 20A Maui Street, Pukete, Hamilton 3200, New Zealand.
  • Dittmer KE; School of Veterinary Sciences, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand.
  • Graff EC; Department of Pathobiology, College of Veterinary Medicine, 166 Greene Hall, Auburn University, AL, USA 36849; Scott-Ritchey Research Center, College of Veterinary Medicine, Dr. Auburn University, 1265 HC Morgan, AL, USA 36849. Electronic address: ecg0001@auburn.edu.
Domest Anim Endocrinol ; 89: 106872, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39059301
ABSTRACT
Fibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Canonical and intracellular FGFs have primarily autocrine or paracrine effects. However, the FGF19 subfamily, composed of FGF15/19, FGF21, and FGF23, act as endocrine hormones that regulate bile acid, metabolic, and phosphorus homeostasis, respectively. Current research in human and rodent models demonstrates the potential of these endocrine FGFs to target various diseases, including disorders of inherited hypophosphatemia, chronic liver disease, obesity, and insulin resistance. Many diseases targeted for therapeutic use in humans have pathophysiological overlaps in domestic animals. Despite the potential clinical and economic impact, little is known about endocrine FGFs and their signaling pathways in major domestic animal species compared with humans and laboratory animals. This review aims to describe the physiology of these endocrine FGFs, discuss their current therapeutic use, and summarize the contemporary literature regarding endocrine FGFs in domestic animals, focusing on potential future directions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Crecimiento de Fibroblastos / Animales Domésticos Límite: Animals / Humans Idioma: En Revista: Domest Anim Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Crecimiento de Fibroblastos / Animales Domésticos Límite: Animals / Humans Idioma: En Revista: Domest Anim Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos