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Enhancing Bioactivity of N,N,N-Chelating Rhodium(III) Complexes with Ionic Liquids: Toward Targeted Cancer Therapy.
Cakovic, Angelina; Cocic, Dusan; Zivanovic, Marko; Jankovic, Nenad; Milivojevic, Nevena; Delibasic, Marija; Kostic, Marina; Radojevic, Ivana; Grujovic, Mirjana; Markovic, Katarina G; Klisuric, Olivera R; Vranes, Milan; Bogojeski, Jovana.
Afiliación
  • Cakovic A; University of Kragujevac, Faculty of Science, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
  • Cocic D; University of Kragujevac, Faculty of Science, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
  • Zivanovic M; University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
  • Jankovic N; University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
  • Milivojevic N; University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
  • Delibasic M; University of Belgrade, Faculty of Biology, Center for Forensic and Applied Molecular Genetics, Studentski trg 16, 11000 Belgrade, Serbia.
  • Kostic M; University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
  • Radojevic I; University of Kragujevac, Faculty of Science, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
  • Grujovic M; University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
  • Markovic KG; University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
  • Klisuric OR; University of Novi Sad, Faculty of Sciences, Department of Physics, Trg Dositeja Obradovica 4, 21000 Novi Sad, Serbia.
  • Vranes M; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
  • Bogojeski J; University of Kragujevac, Faculty of Science, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
J Med Chem ; 67(15): 13349-13362, 2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39058952
ABSTRACT
This study investigates the potential of using ionic liquids as cosolvents to enhance the solubility and activity of poorly soluble rhodium(III) complexes, particularly those with diene, pyridine derivatives, and camphor-derived bis-pyrazolylpyridine ligands, in relation to 5'-GMP, CT-DNA, and HSA as well as their biological activity. Findings indicate that ionic liquids significantly increase the substitution activity of these complexes toward 5'-GMP while only marginally affecting DNA/HSA binding affinities with molecular docking, further confirming the experimental results. Lipophilicity assessments indicated good lipophilicity. Notably, cytotoxicity studies show that Rh2 is selectively effective against HeLa cancer cells, with IL1 and IL10 modulating the cytotoxic effects. Redox evaluations indicate that rhodium complexes induce oxidative stress in cancerous cells while maintaining redox balance in noncancerous cells. By elucidating the role of ionic liquids in modulating these effects, the study proposes a promising avenue for augmenting the efficacy and selectivity of cancer treatments, thus opening new horizons in cancer therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rodio / Líquidos Iónicos / Complejos de Coordinación / Antineoplásicos Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rodio / Líquidos Iónicos / Complejos de Coordinación / Antineoplásicos Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos