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Timing and location dictate monocyte fate and their transition to tumor-associated macrophages.
Dunsmore, Garett; Guo, Wei; Li, Ziyi; Bejarano, David Alejandro; Pai, Rhea; Yang, Katharine; Kwok, Immanuel; Tan, Leonard; Ng, Melissa; De La Calle Fabregat, Carlos; Yatim, Aline; Bougouin, Antoine; Mulder, Kevin; Thomas, Jake; Villar, Javiera; Bied, Mathilde; Kloeckner, Benoit; Dutertre, Charles-Antoine; Gessain, Grégoire; Chakarov, Svetoslav; Liu, Zhaoyuan; Scoazec, Jean-Yves; Lennon-Dumenil, Ana-Maria; Marichal, Thomas; Sautès-Fridman, Catherine; Fridman, Wolf Herman; Sharma, Ankur; Su, Bing; Schlitzer, Andreas; Ng, Lai Guan; Blériot, Camille; Ginhoux, Florent.
Afiliación
  • Dunsmore G; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Guo W; Université Paris-Saclay, Ile-de-France, France.
  • Li Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Bejarano DA; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Pai R; Quantitative Systems Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.
  • Yang K; Curtin Medical School, Curtin University, Bentley, WA, Australia.
  • Kwok I; Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.
  • Tan L; Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.
  • Ng M; Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.
  • De La Calle Fabregat C; Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.
  • Yatim A; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Bougouin A; Institut Curie, PSL University, INSERM U932, Immunity and Cancer, 75005 Paris, France.
  • Mulder K; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.
  • Thomas J; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Villar J; Université Paris-Saclay, Ile-de-France, France.
  • Bied M; Quantitative Systems Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.
  • Kloeckner B; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Dutertre CA; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Gessain G; Université Paris-Saclay, Ile-de-France, France.
  • Chakarov S; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Liu Z; Université Paris-Saclay, Ile-de-France, France.
  • Scoazec JY; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Lennon-Dumenil AM; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Marichal T; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Sautès-Fridman C; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Fridman WH; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
  • Sharma A; Institut Curie, PSL University, INSERM U932, Immunity and Cancer, 75005 Paris, France.
  • Su B; Laboratory of Immunophysiology, GIGA Institute, Liège University, Liège, Belgium.
  • Schlitzer A; Faculty of Veterinary Medicine, Liège University, Liège, Belgium.
  • Ng LG; Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium.
  • Blériot C; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.
  • Ginhoux F; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.
Sci Immunol ; 9(97): eadk3981, 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-39058763
ABSTRACT
Tumor-associated macrophages (TAMs) are a heterogeneous population of cells whose phenotypes and functions are shaped by factors that are incompletely understood. Herein, we asked when and where TAMs arise from blood monocytes and how they evolve during tumor development. We initiated pancreatic ductal adenocarcinoma (PDAC) in inducible monocyte fate-mapping mice and combined single-cell transcriptomics and high-dimensional flow cytometry to profile the monocyte-to-TAM transition. We revealed that monocytes differentiate first into a transient intermediate population of TAMs that generates two longer-lived lineages of terminally differentiated TAMs with distinct gene expression profiles, phenotypes, and intratumoral localization. Transcriptome datasets and tumor samples from patients with PDAC evidenced parallel TAM populations in humans and their prognostic associations. These insights will support the design of new therapeutic strategies targeting TAMs in PDAC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Monocitos / Carcinoma Ductal Pancreático / Macrófagos Asociados a Tumores Límite: Animals / Humans Idioma: En Revista: Sci Immunol Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Monocitos / Carcinoma Ductal Pancreático / Macrófagos Asociados a Tumores Límite: Animals / Humans Idioma: En Revista: Sci Immunol Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos