Synthesis and characterization of nano-biopolymer carriers loaded with clove (Syzygium aromaticum L.) extract as an anticancer agent: an in vitro study.
J Biomater Sci Polym Ed
; 35(15): 2363-2379, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39058583
ABSTRACT
The objective of this work was to design a new drug nanoparticle (NP) composed of chitosan/ß-cyclodextrin/sodium tripolyphosphate/alginate (CS/ßCD/TPP/AL) loaded with a clove extract (CE) for potential anticancer effects. The extract was prepared by two extraction methods:
hydroalcoholic maceration (MAC) with 80% MeOH and supercritical fluid (SCF). The MACCE and SCFCE CE NPs had particle sizes of 71 nm and 20 nm, respectively with irregular spherical shapes. The nanocarriers achieved entrapment efficiencies of over 90%. MACCE-NPs and SCFCE-NPs released 18.35% and 10.12% of the extract after 6 h, respectively. Cell viability decreased to 54%, 7%, and 12% in HeLa, U87, and KB cell lines, respectively, after a 48-hour treatment with SCFCE-NPs and 75%, 8%, and 17% after treatment with MACCE-NPs, significantly reduced compared to the control. It is concluded that NPs containing CE exhibit a higher degree of toxicity due to better penetration into cells.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Extractos Vegetales
/
Supervivencia Celular
/
Syzygium
/
Quitosano
/
Nanopartículas
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
J Biomater Sci Polym Ed
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Reino Unido