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Tumor morphology evaluation using 3D-morphometric features of renal masses.
Dmitry, Fiev; Evgeniy, Sirota; Vasiliy, Kozlov; Alexandra, Proskura; Khalil, Ismailov; Evgeny, Shpot; Mikhail, Chernenkiy; Kirill, Puzakov; Alexander, Tarasov; Dmitry, Korolev; Camilla, Azilgareeva; Andrey, Vinarov; Denis, Butnaru; Petr, Glybochko; Leonid, Rapoport.
Afiliación
  • Dmitry F; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Evgeniy S; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Vasiliy K; Semashko Department of Public Health and Healthcare, Sechenov University, Moscow, Russia.
  • Alexandra P; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Khalil I; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Evgeny S; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Mikhail C; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Kirill P; Department of Radiology, The Second University Clinic, Sechenov University, Moscow, Russia.
  • Alexander T; Institute of Linguistics and Intercultural Communication, Sechenov University, Moscow, Russia.
  • Dmitry K; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Camilla A; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Andrey V; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Denis B; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Petr G; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
  • Leonid R; Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
Urologia ; : 3915603241261499, 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-39058231
ABSTRACT

OBJECTIVE:

To assess the correlation between the general (gender, age, and maximum tumor size) and 3D morphotopometric features of the renal tumor node, following the MSCT data post-processing, and the tumor histological structure; to propose an equation allowing for kidney malignancy assessment based on general and morphometric features. MATERIALS AND

METHODS:

In total, 304 patients with unilateral solitary renal neoplasms underwent laparoscopic (retroperitoneoscopic) or robotic partial or radical nephrectomy. Before the procedure, kidney contrast-enhanced MSCT followed by the tumor 3D-modeling was performed. 3D model of the kidney tumor, and its morphotopometric features, and histological structure were analyzed. The morphotopometric ones include the side of the lesion, location by segments, the surface where the tumor, the depth of the tumor invasion into the kidney, and the shape of tumor.

RESULTS:

Out of 304 patients, 254 (83.6%) had malignant kidney tumors and 50 (16.4%) benign kidney tumors. In total, 231 patients, out of 254 (90.9%) were assessed for the degree of malignant tumor differentiation. Malignant tumors were more frequent in men than in women (p < 0.001). Mushroom-shaped tumors were the most common shapes among benign renal masses (35.2%). The most common malignant kidney tumors had spherical with a partially uneven surface (27.6%), multinodular (tuberous (27.2%)), and spherical with a conical base (24.8%) shapes. Logistic regression model enabled the development of prognostic equation for tumor malignancy prediction ("low" or "high"). The univariate analysis revealed the correlation only between high differentiation (G1) and a spherical tumor with a conical base (p = 0.029).

CONCLUSION:

The resulting logistic model, based on the analysis of such predictors as gender and form of kidney lesions, demonstrated a large share (87.6%) of correct predictions of the kidney tumor malignancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Urologia Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Urologia Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos