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Ultra-High Contrast MRI: The Whiteout Sign Shown with Divided Subtracted Inversion Recovery (dSIR) Sequences in Post-Insult Leukoencephalopathy Syndromes (PILS).
Condron, Paul; Cornfeld, Daniel M; Scadeng, Miriam; Melzer, Tracy R; Newburn, Gil; Bydder, Mark; Kwon, Eryn E; McGeown, Joshua P; Handsfield, Geoffrey G; Emsden, Taylor; Tayebi, Maryam; Holdsworth, Samantha J; Bydder, Graeme M.
Afiliación
  • Condron P; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
  • Cornfeld DM; Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.
  • Scadeng M; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
  • Melzer TR; Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.
  • Newburn G; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
  • Bydder M; Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.
  • Kwon EE; Department of Medicine, University of Otago, Christchurch 8011, New Zealand.
  • McGeown JP; New Zealand Brain Research Institute, Christchurch 8011, New Zealand.
  • Handsfield GG; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
  • Emsden T; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
  • Tayebi M; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
  • Holdsworth SJ; Auckland Bioengineering Institute, University of Auckland, Auckland 1010, New Zealand.
  • Bydder GM; Matai Medical Research Institute, Tairawhiti Gisborne 4010, New Zealand.
Tomography ; 10(7): 983-1013, 2024 Jun 26.
Article en En | MEDLINE | ID: mdl-39058046
ABSTRACT
Ultra-high contrast (UHC) MRI describes forms of MRI in which little or no contrast is seen on conventional MRI images but very high contrast is seen with UHC techniques. One of these techniques uses the divided subtracted inversion recovery (dSIR) sequence, which, in modelling studies, can produce ten times the contrast of conventional inversion recovery (IR) sequences. When used in cases of mild traumatic brain injury (mTBI), the dSIR sequence frequently shows extensive abnormalities in white matter that appears normal when imaged with conventional T2-fluid-attenuated IR (T2-FLAIR) sequences. The changes are bilateral and symmetrical in white matter of the cerebral and cerebellar hemispheres. They partially spare the anterior and posterior central corpus callosum and peripheral white matter of the cerebral hemispheres and are described as the whiteout sign. In addition to mTBI, the whiteout sign has also been seen in methamphetamine use disorder and Grinker's myelinopathy (delayed post-hypoxic leukoencephalopathy) in the absence of abnormalities on T2-FLAIR images, and is a central component of post-insult leukoencephalopathy syndromes. This paper describes the concept of ultra-high contrast MRI, the whiteout sign, the theory underlying the use of dSIR sequences and post-insult leukoencephalopathy syndromes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Leucoencefalopatías Límite: Humans Idioma: En Revista: Tomography Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Leucoencefalopatías Límite: Humans Idioma: En Revista: Tomography Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Suiza