Your browser doesn't support javascript.
loading
Development and evaluation of berberine-loaded bigel for the treatment of hyperpigmentation on B16F10 melanoma cell line.
Mangla, Bharti; Kumar, Pankaj; Ahamad, Zuber; Javed, Shamama; Ahsan, Waquar; Aggarwal, Geeta.
Afiliación
  • Mangla B; Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University (DPSRU), New Delhi, 110017, India.
  • Kumar P; Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University (DPSRU), New Delhi, 110017, India.
  • Ahamad Z; Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University (DPSRU), New Delhi, 110017, India.
  • Javed S; Department of Pharmaceutics, College of Pharmacy, Jazan University, P. Box No. 114, Jazan, Saudi Arabia.
  • Ahsan W; Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, P. Box No. 114, Jazan, Saudi Arabia.
  • Aggarwal G; Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University (DPSRU), New Delhi, 110017, India.
Nanomedicine (Lond) ; 19(18-20): 1659-1673, 2024.
Article en En | MEDLINE | ID: mdl-39056145
ABSTRACT

Aim:

The aim of this study was to optimize, develop, characterize and evaluate a topical nanobigel (BG) formulation containing Berberine (BRB) that exhibits anti-melanogenic properties.Materials &

methods:

The Berberine-loaded bigel (BRB@BG) formulation was prepared by homogenously mixing the optimized hydrogel and oleogel. BRB@BG was characterized in vitro and cytotoxicity study was conducted to evaluate its effects on murine skin melanoma B16F10 cell lines.

Results:

The optimized BRB@BG exhibited uniform texture with nanometric size, desirable spreadability and extrudability, suitable for topical applications. Cytotoxicity studies revealed that BRB@BG had a lower IC50 value (4.84 µg/ml) on B16F10 cell lines compared with drug alone.

Conclusion:

In conclusion, the developed BRB@BG formulation showed good potential as safe and effective topical treatment for hyperpigmentation.
Hyperpigmentation is a common skin disease in which the melanin content becomes abnormally high. The existing treatment options are associated with side effects and therefore research is being aimed to develop a topical nanoformulation based on natural compounds. Berberine (BRB) is one such natural compound that is known to inhibit the production of melanin in skin. This study was aimed to develop a bigel formulation of BRB that can be applied on skin, which can treat the hyperpigmentation and is safe. The developed nanomedicine was found to have all good properties of a topical formulation and was more effective than the drug alone. Various studies on animals were conducted to assess its safety and it was found that the formulation did not show any toxicity to the skin.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Berberina / Melanoma Experimental / Hiperpigmentación Límite: Animals / Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Berberina / Melanoma Experimental / Hiperpigmentación Límite: Animals / Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido