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Prevalence of chronic kidney disease and associated risk factors among people living with HIV in a rural population of Limpopo Province, South Africa.
Choshi, Joel; Flepisi, Brian; Mabhida, Sihle E; Sekgala, Machoene D; Mokoena, Haskly; Nkambule, Bongani B; Ndwandwe, Duduzile; Mchiza, Zandile J; Nqebelele, Unati; Kengne, André P; Dludla, Phiwayinkosi V; Hanser, Sidney.
Afiliación
  • Choshi J; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, South Africa.
  • Flepisi B; Department of Pharmacology, University of Pretoria, Pretoria, South Africa.
  • Mabhida SE; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.
  • Sekgala MD; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.
  • Mokoena H; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, South Africa.
  • Nkambule BB; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • Ndwandwe D; Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa.
  • Mchiza ZJ; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.
  • Nqebelele U; School of Public Health, University of the Western Cape, Bellville, South Africa.
  • Kengne AP; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.
  • Dludla PV; Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Hanser S; Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Front Public Health ; 12: 1425460, 2024.
Article en En | MEDLINE | ID: mdl-39056083
ABSTRACT

Background:

Limited evidence informs on the prevalence of chronic kidney disease (CKD) in people living with HIV (PLWH) in South Africa. Thus, this study aimed to determine the prevalence of CKD and its associated risk factors among PLWH within the rural province of Limpopo, South Africa.

Methods:

We conducted a cross-sectional study of 143 participants, subdivided into groups of PLWH (n = 103) and individuals without HIV (n = 43). Structured questionnaires were used to collect and capture sociodemographic information including age, sex, alcohol intake, smoking status, and educational status. Basic measurements taken included levels of cluster of differentiation 4 (CD4+) count, body mass index (BMI), blood pressure, plasma cystatin C, and fasting serum glucose levels. Plasma cystatin C-based estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD-EPI) estimator to determine the prevalence of CKD.

Results:

The prevalence of CKD was approximately 7% in PLWH. Multivariate logistic regression analysis showed that it was only diabetes mellitus (odds ratio of 5.795, 95% confidence interval, p = 0.034) and age (odds ratio of 1.078, 95% confidence interval, p = 0.039) that were significantly associated with CKD in PLWH.

Conclusion:

Chronic kidney disease was prevalent in PLWH, and it was further associated with cardiovascular risk factors, diabetes, and ageing. As PLWH age, the burden of CKD may be increased with the increase in cardiovascular-related comorbidities such as diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural / Infecciones por VIH / Insuficiencia Renal Crónica Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Front Public Health Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural / Infecciones por VIH / Insuficiencia Renal Crónica Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Front Public Health Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Suiza