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Ex Situ Left Ventricular Pressure-Volume Loop Analyses for Donor Hearts: Proof of Concept in an Ovine Experimental Model.
Ertugrul, I A; Puspitarani, R A D A; Wijntjes, B; Vervoorn, M T; Ballan, E M; van der Kaaij, N P; van Goor, H; Westenbrink, B D; van der Plaats, A; Nijhuis, F; van Suylen, V; Erasmus, M E.
Afiliación
  • Ertugrul IA; Department of Cardiothoracic Surgery, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.
  • Puspitarani RADA; Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.
  • Wijntjes B; XVIVO, Gothenburg, Sweden.
  • Vervoorn MT; Department of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, Netherlands.
  • Ballan EM; Department of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, Netherlands.
  • van der Kaaij NP; Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, Netherlands.
  • van Goor H; Netherlands Heart Institute, Utrecht, Netherlands.
  • Westenbrink BD; Department of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, Netherlands.
  • van der Plaats A; Department of Medical Biology and Pathology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.
  • Nijhuis F; Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.
  • van Suylen V; XVIVO, Gothenburg, Sweden.
  • Erasmus ME; XVIVO, Gothenburg, Sweden.
Transpl Int ; 37: 12982, 2024.
Article en En | MEDLINE | ID: mdl-39055346
ABSTRACT
Ex situ heart perfusion (ESHP) has emerged as an important strategy to preserve donation after brain death (DBD) and donation after circulatory death (DCD) donor hearts. Clinically, both DBD and DCD hearts are successfully preserved using ESHP. Viability assessment is currently based on biochemical values, while a reliable method for graft function assessment in a physiologic working mode is unavailable. As functional assessment during ESHP has demonstrated the highest predictive value of outcome post-transplantation, this is an important area for improvement. In this study, a novel method for ex situ assessment of left ventricular function with pressure-volume loop analyses is evaluated. Ovine hearts were functionally evaluated during normothermic ESHP with the novel pressure-volume loop system. This system provides an afterload and adjustable preload to the left ventricle. By increasing the preload and measuring end-systolic elastance, the system could successfully assess the left ventricular function. End-systolic elastance at 60 min and 120 min was 2.8 ± 1.8 mmHg/mL and 2.7 ± 0.7 mmHg/mL, respectively. In this study we show a novel method for functional graft assessment with ex situ pressure-loop analyses during ESHP. When further validated, this method for pressure-volume assessments, could be used for better graft selection in both DBD and DCD donor hearts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preservación de Órganos / Función Ventricular Izquierda / Trasplante de Corazón Límite: Animals Idioma: En Revista: Transpl Int Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preservación de Órganos / Función Ventricular Izquierda / Trasplante de Corazón Límite: Animals Idioma: En Revista: Transpl Int Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza