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Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals.
Zhang, Jun-Zhe; Li, Yu-Zhen; Xi, Zhi-Ning; Gao, Hui-Peng; Zhang, Quan; Liu, Li-Cheng; Li, Fu-Li; Ma, Xiao-Qing.
Afiliación
  • Zhang JZ; Qingdao C1 Refinery Engineering Research Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
  • Li YZ; University of Chinese Academy of Sciences, Beijing, China.
  • Xi ZN; Qingdao C1 Refinery Engineering Research Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
  • Gao HP; University of Chinese Academy of Sciences, Beijing, China.
  • Zhang Q; Qingdao C1 Refinery Engineering Research Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
  • Liu LC; Sinopec Dalian (Fushun) Research Institute of Petroleum and Petrochemicals, Dalian, China.
  • Li FL; Sinopec Dalian (Fushun) Research Institute of Petroleum and Petrochemicals, Dalian, China.
  • Ma XQ; Key Laboratory of Marine Chemistry Theory and Technology (Ministry of Education), College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, China.
Front Bioeng Biotechnol ; 12: 1395540, 2024.
Article en En | MEDLINE | ID: mdl-39055341
ABSTRACT
Acetogenic bacteria (acetogens) are a class of microorganisms with conserved Wood-Ljungdahl pathway that can utilize CO and CO2/H2 as carbon source for autotrophic growth and convert these substrates to acetate and ethanol. Acetogens have great potential for the sustainable production of biofuels and bulk biochemicals using C1 gases (CO and CO2) from industrial syngas and waste gases, which play an important role in achieving carbon neutrality. In recent years, with the development and improvement of gene editing methods, the metabolic engineering of acetogens is making rapid progress. With introduction of heterogeneous metabolic pathways, acetogens can improve the production capacity of native products or obtain the ability to synthesize non-native products. This paper reviews the recent application of metabolic engineering in acetogens. In addition, the challenges of metabolic engineering in acetogens are indicated, and strategies to address these challenges are also discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza