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Spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle.
Caserta, Leonardo C; Frye, Elisha A; Butt, Salman L; Laverack, Melissa; Nooruzzaman, Mohammed; Covaleda, Lina M; Thompson, Alexis C; Koscielny, Melanie Prarat; Cronk, Brittany; Johnson, Ashley; Kleinhenz, Katie; Edwards, Erin E; Gomez, Gabriel; Hitchener, Gavin; Martins, Mathias; Kapczynski, Darrell R; Suarez, David L; Alexander Morris, Ellen Ruth; Hensley, Terry; Beeby, John S; Lejeune, Manigandan; Swinford, Amy K; Elvinger, François; Dimitrov, Kiril M; Diel, Diego G.
Afiliación
  • Caserta LC; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Frye EA; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Butt SL; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Laverack M; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Nooruzzaman M; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Covaleda LM; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Thompson AC; Texas A&M Veterinary Medical Diagnostic Laboratory, Canyon, TX, USA.
  • Koscielny MP; Ohio Animal Disease and Diagnostic Laboratory, Ohio Department of Agriculture, Reynoldsburg, OH, USA.
  • Cronk B; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Johnson A; Ohio Animal Disease and Diagnostic Laboratory, Ohio Department of Agriculture, Reynoldsburg, OH, USA.
  • Kleinhenz K; Texas A&M Veterinary Medical Diagnostic Laboratory, Canyon, TX, USA.
  • Edwards EE; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
  • Gomez G; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
  • Hitchener G; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Martins M; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
  • Kapczynski DR; Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, United States Department of Agriculture, Athens, GA, USA.
  • Suarez DL; Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, United States Department of Agriculture, Athens, GA, USA.
  • Alexander Morris ER; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
  • Hensley T; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
  • Beeby JS; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Lejeune M; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Swinford AK; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
  • Elvinger F; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Dimitrov KM; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA. kiril.dimitrov@tvmdl.tamu.edu.
  • Diel DG; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. dgdiel@cornell.edu.
Nature ; 2024 Jul 25.
Article en En | MEDLINE | ID: mdl-39053575
ABSTRACT
Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b virus has caused the death of millions of domestic birds and thousands of wild birds in the U.S. since January, 20221-4 Throughout this outbreak, spillovers to mammals have been frequently documented5-12. We report spillover of HPAI H5N1 virus in dairy cattle herds across several states in the U.S. The affected cows displayed clinical signs encompassing decreased feed intake, altered fecal consistency, respiratory distress, and decreased milk production with abnormal milk. Infectious virus and viral RNA were consistently detected in milk from affected cows. Viral distribution in tissues via immunohistochemistry and in situ hybridization revealed a distinct tropism of the virus for the epithelial cells lining the alveoli of the mammary gland in cows. Whole viral genome sequences recovered from dairy cows, birds, domestic cats, and a raccoon from affected farms indicated multidirectional interspecies transmissions. Epidemiologic and genomic data revealed efficient cow-to-cow transmission after apparently healthy cows from an affected farm were transported to a premise in a different state. These results demonstrate the transmission of HPAI H5N1 clade 2.3.4.4b virus at a non-traditional interface underscoring the ability of the virus to cross species barriers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nature Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nature Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido