Static autoregulation in humans.

Paulson, Olaf B; Strandgaard, Svend; Olesen, Jes; Baron, Jean-Claude

Paulson, Olaf B; Strandgaard, Svend; Olesen, Jes; Baron, Jean-Claude.

Afiliación

Paulson OB; Neurobiology Research Unit, Department of Neurology, Rigshospitalet Blegdamsvej, Copenhagen, Denmark.
Strandgaard S; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Olesen J; Department of Nephrology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark.
Baron JC; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

J Cereb Blood Flow Metab ; : 271678X241258701, 2024 Jul 25.

Article en En | MEDLINE | ID: mdl-39053494

ABSTRACT

ABSTRACT

A recent publication in JCBFM, "Static autoregulation in humans" gives rise to critical comments. Autoregulation of cerebral blood flow implies that flow is rather constant within a certain blood pressure (BP) range with a lower and an upper pressure limit. The physiology at the two limits is very different, making comparison of the brain's vulnerability at the limits questionable. The recent publication in JCBFM claims a narrow autoregulatory range based on pooling of data from several studies. However, we argue that such pooling blurs the autoregulatory limits. We summarize the classical literature, therefrom we argue for a broad autoregulatory range.

Palabras clave

Autoregulation; cerebral autoregulation; cerebral blood flow regulation; cerebral hemodynamics; hemodynamics; meta-analysis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos

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