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Two-year mortality and seizure recurrence following status epilepticus in Auckland, New Zealand: A prospective cohort study.
Zhang, Tony; Ajamain, Adi Wa'ie Hj; Donnelly, Joseph; Brockington, Alice; Jayabal, Jayaganth; Scott, Shona; Brennan, Mary; Litchfield, Rhonda; Beilharz, Erica; Dalziel, Stuart R; Jones, Peter; Yates, Kim; Thornton, Vanessa; Bergin, Peter S.
Afiliación
  • Zhang T; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand; Centre for Brain Research, University of Auckland, Auckland, New Zealand.
  • Ajamain AWH; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand.
  • Donnelly J; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand; Centre for Brain Research, University of Auckland, Auckland, New Zealand.
  • Brockington A; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand; Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, United Kingdom.
  • Jayabal J; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand; Pantai-Gleneagles Hospital, Penang and Sungai Petani, Kedah, Malaysia.
  • Scott S; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand; Western General Hospital, Edinburgh, United Kingdom.
  • Brennan M; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand.
  • Litchfield R; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand.
  • Beilharz E; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand.
  • Dalziel SR; Department of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand; Starship Children's Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand.
  • Jones P; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand.
  • Yates K; North Shore and Waitakere Emergency Departments, Te Whatu Ora Waitemata, Auckland, New Zealand.
  • Thornton V; Middlemore Hospital, Te Whatu Ora Counties Manukau, Auckland, New Zealand.
  • Bergin PS; Auckland City Hospital, Te Whatu Ora Te Toka Tumai, Grafton, Auckland, New Zealand; Centre for Brain Research, University of Auckland, Auckland, New Zealand. Electronic address: pbergin@adhb.govt.nz.
Seizure ; 121: 17-22, 2024 Jul 21.
Article en En | MEDLINE | ID: mdl-39053336
ABSTRACT

PURPOSE:

To document the 2-year mortality and seizure recurrence rate of a prospective cohort of patients identified with status epilepticus (SE).

METHODS:

Patients presenting to any hospital in the Auckland region between April 6 2015, and April 5 2016, with a seizure lasting 10 min or longer were identified. Follow up was at 2 years post index SE episode via telephone calls and detailed review of clinical notes.

RESULTS:

We identified 367 patients with SE over the course of one year. 335/367 (91.3 %) were successfully followed up at the 2-year mark. Two-year all-cause mortality was 50/335 (14.9 %), and 49/267 (18.4 %) when febrile SE was excluded. Two-year seizure recurrence was 197/335 (58.8 %). On univariate analyses, children (preschoolers 2 to < 5 years and children 5 to < 15 years), Asian ethnicity, SE duration <30 mins and acute (febrile) aetiology were associated with lower mortality, while older age >60 and progressive causes were associated with higher mortality on both univariate and multivariate analyses. Age < 2 years and acute aetiology were associated with lower seizure recurrence, while non convulsive status epilepticus (NCSE) with coma and a history of epilepsy were associated with higher seizure recurrence. On multivariate analyses, a history of epilepsy, as well as having both acute and remote causes were associated with higher seizure recurrence.

CONCLUSIONS:

All-cause mortality in both the paediatric and adult populations at 2 years was lower than most previous reports. Older age, SE duration ≥30 mins and progressive aetiologies were associated with the highest 2-year mortality, while febrile SE had the lowest mortality. A history of epilepsy, NCSE with coma, and having both acute and remote causes were associated with higher seizure recurrence at 2 years. Future studies should focus on functional measures of outcome and long-term quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Seizure Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Seizure Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido