Your browser doesn't support javascript.
loading
Functional and structural brain connectivity in disorders of consciousness.
Altmayer, Victor; Sangare, Aude; Calligaris, Charlotte; Puybasset, Louis; Perlbarg, Vincent; Naccache, Lionel; Sitt, Jacobo Diego; Rohaut, Benjamin.
Afiliación
  • Altmayer V; Sorbonne University, Paris, F-75013, France.
  • Sangare A; Department of Neurology, AP-HP, Pitié-Salpêtrière Hospital, Neuro-ICU, Paris, F-75013, France.
  • Calligaris C; Sorbonne University, Paris, F-75013, France.
  • Puybasset L; Department of Neurophysiology, AP-HP, Pitié-Salpêtrière Hospital, Paris, F-75013, France.
  • Perlbarg V; PICNIC-Lab, Paris Brain Institute, (ICM), INSERM, CNRS, Hôpital Pitié Salpêtrière, 47 bvd de l'hôpital, Paris, F-75013, France.
  • Naccache L; Sorbonne University, Paris, F-75013, France.
  • Sitt JD; Department of Neurology, AP-HP, Pitié-Salpêtrière Hospital, Neuro-ICU, Paris, F-75013, France.
  • Rohaut B; Sorbonne University, Paris, F-75013, France.
Brain Struct Funct ; 2024 Jul 25.
Article en En | MEDLINE | ID: mdl-39052096
ABSTRACT
Brain connectivity, allowing information to be shared between distinct cortical areas and thus to be processed in an integrated way, has long been considered critical for consciousness. However, the relationship between functional intercortical interactions and the structural connections thought to underlie them is poorly understood. In the present work, we explore both functional (with an EEG-based metric the median weighted symbolic mutual information in the theta band) and structural (with a brain MRI-based metric fractional anisotropy) connectivities in a cohort of 78 patients with disorders of consciousness. Both metrics could distinguish patients in a vegetative state from patients in minimally conscious state. Crucially, we discovered a significant positive correlation between functional and structural connectivities. Furthermore, we showed that this structure-function relationship is more specifically observed when considering structural connectivity within the intra- and inter-hemispheric long-distance cortico-cortical bundles involved in the Global Neuronal Workspace (GNW) theory of consciousness, thus supporting predictions of this model. Altogether, these results support the interest of multimodal assessments of brain connectivity in refining the diagnostic evaluation of patients with disorders of consciousness.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania