A prospective study of the immunogenicity of porcine insulin in HLA-typed new insulin-treated diabetics.
Diabetes Res
; 2(5): 221-4, 1985 Sep.
Article
en En
| MEDLINE
| ID: mdl-3905185
Fifty-four diabetics were started on insulin therapy with highly purified porcine insulin (Velosulin, Insulatard, Mixtard) and treated for at least 1 yr with blood samples drawn at regular intervals for insulin antibody determinations. In 43 patients the insulin antibody response was correlated with HLA A, B, and DR antigens. Approximately half of the patients formed insulin antibodies within 6 months of treatment, and this incidence remained constant for up till 2 yr. In those patients who developed insulin antibodies a plateau of 12% insulin binding capacity was reached after 9-12 months which remained constant for up till 2 yr. Formation of antibodies to proinsulin and pancreatic polypeptide proved completely avoidable, and no local reactions at the injection sites were observed. There was indication of a positive association between HLA DR4 tissue types and the tendency to immune response to injected insulin (p = 0.07).
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 1
/
Antígenos HLA
/
Insulina
/
Anticuerpos Insulínicos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Diabetes Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Reino Unido